C15orf44 Inhibitors

Integrator complex subunit 14 (INTS14) is a component of the integrator complex, a multiprotein assembly that plays a pivotal role in the processing of small nuclear RNAs (snRNAs), transcriptional regulation, and genome maintenance. INTS14 is one of the subunits of this complex and contributes to its diverse functions.The integrator complex is known for its essential role in the 3' end processing of uridine-rich small nuclear RNAs (U snRNAs), which are a component of the spliceosome, the cellular machinery responsible for the removal of introns from pre-messenger RNA (pre-mRNA). This processing is critical for the maturation of snRNAs, enabling them to form complexes with spliceosomal proteins and participate effectively in pre-mRNA splicing.

Beyond snRNA processing, INTS14 and the integrator complex are implicated in the regulation of gene expression at multiple levels. The complex has been shown to be associated with RNA polymerase II (Pol II) and is believed to play a role in transcription elongation as well as termination. It can influence chromatin architecture and has been linked to the regulation of enhancer RNAs (eRNAs), which are involved in the control of gene expression by enhancers.Recent studies suggest that the integrator complex, including INTS14, may also be involved in DNA repair and genome stability. The complex has been observed to localize to sites of DNA damage, suggesting a potential role in the cellular response to genotoxic stress.Alterations in the function or expression of INTS14 could have significant consequences for cell function and viability, potentially leading to diseases such as cancer. Given its involvement in fundamental cellular processes, INTS14 and the integrator complex are subjects of interest in the fields of molecular biology and pathology, with research ongoing to elucidate their roles in health and disease.