C14orf148 Inhibitors

NADP Dependent Oxidoreductase Domain Containing 1, often abbreviated as NOR1, is an enzyme that belongs to the family of oxidoreductases. These enzymes are characterized by their ability to catalyze oxidation-reduction reactions, which are fundamental to cellular metabolism. Oxidoreductases play critical roles in various metabolic pathways, including those involved in the metabolism of lipids, amino acids, and carbohydrates, as well as in the detoxification of drugs and xenobiotics.NOR1 specifically is known to contain domains that suggest its activity is dependent on nicotinamide adenine dinucleotide phosphate (NADP+), which is a coenzyme used in anabolic reactions, such as lipid and nucleic acid synthesis, where it functions as an electron donor. The enzyme's activity is also associated with the reduction of reactive oxygen species (ROS), protecting cells from oxidative damage. This protection is vital for maintaining cellular integrity and function, as excessive ROS can lead to oxidative stress, damaging DNA, proteins, and lipids, which in turn is implicated in aging and various diseases including cancer and neurodegenerative disorders.

The precise molecular function of NOR1, as well as the pathways it is involved in and its biological substrates, are still under active investigation. However, it is believed that NOR1's enzymatic activity may involve the conversion of aldehydes and ketones to their corresponding alcohols using NADP+ as a cofactor, reflecting its role in cellular redox homeostasis.Understanding the function of NOR1 is of interest not only for basic science in elucidating the complex network of redox reactions within the cell. Given its potential role in mitigating oxidative stress, NOR1 may be a target for interventions aimed at diseases caused by or associated with oxidative damage.