C14orf145 Inhibitors

C14orf145 is a protein whose activity is intricately linked to the mTOR signaling pathway, a central regulator of cell growth and metabolism. Inhibition of mTOR not only disrupts the downstream signaling cascade but also directly impacts the functional activity of C14orf145. Specific inhibitors target the mTOR complex, directly impeding its kinase activity, which in turn diminishes the downstream effects necessary for C14orf145-mediated cellular processes. These inhibitors work by forming complexes with intracellular proteins like FKBP12, selectively binding to mTOR complex 1, or acting broadly on both mTORC1 and mTORC2. By blocking the phosphorylation events that are crucial for the mTOR pathway, the inhibitors effectively reduce the functional output of C14orf145, thus preventing it from executing its role in cell proliferation and growth.

Furthermore, the inhibition of upstream kinases such as AKT by other compounds leads to a reduction in mTOR activity, which results in decreased C14orf145 signaling. The suppression of AKT phosphorylation indirectly affects C14orf145 by limiting the mTORC1/C2-mediated signaling pathways it relies on for activation and function. The comprehensive inhibition of these signaling pathways, either by dual TORC1/TORC2 inhibitors or ATP-competitive inhibitors that disrupt mTOR's kinase activity, ensures a thorough downregulation of C14orf145 activity.