C11orf42 Inhibitors
C11orf42 inhibitors represent a class of compounds that indirectly affect the functional activity of the C11orf42 protein through the modulation of cellular signaling pathways with which C11orf42 may interact. For example, LY294002 and Wortmannin are both potent inhibitors of the PI3K/AKT pathway, which is critical for numerous cellular functions, including cell survival, growth, and proliferation. Inhibition of this pathway by these compounds could lead to reduced cellular activities that rely on C11orf42 function if it is part of this signaling cascade. Similarly, PD98059 and U0126 target the MEK enzyme, which is pivotal in the MAPK/ERK pathway, a pathway often associated with cell differentiation and proliferation. If C11orf42 operates within this pathway or is regulated by it, the inhibition brought about by these compounds could result in decreased C11orf42 activity.
Additionally, SB203580 and SP600125 specifically target the p38 MAPK and JNK pathways, respectively, both of which are involved in cellular responses to stress and apoptosis. The inhibition of these kinases could lead to a reduction in C11orf42 activity if this protein plays a role in stress response or apoptotic signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphatidylinositol 3-kinase (PI3K). This compound inhibits the PI3K/AKT signaling pathway, which may lead to decreased survival signaling, potentially reducing the functional activity of C11orf42 if it's involved in cell survival processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor that impedes the PI3K/AKT pathway. By inhibiting this pathway, Wortmannin can decrease cell growth and proliferation signals, which could indirectly affect C11orf42 activity if it plays a role in these processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Its action can lead to reduced cell proliferation and differentiation signals that may indirectly influence C11orf42 if it is involved in these pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A specific inhibitor of p38 MAPK. It impedes the p38 MAPK signaling pathway that is involved in inflammation and stress response. This could lead to decreased C11orf42 activity if it is responsive to stress signals. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which affects the JNK signaling pathway related to apoptosis and cell survival. This can indirectly inhibit C11orf42 activity if the protein is involved in these cellular responses. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
A well-known mTOR inhibitor that affects cellular growth and autophagy by inhibiting the mTORC1 complex. If C11orf42 is involved in these cellular processes, its function could be indirectly inhibited. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that prevents the degradation of proteins involved in cell cycle regulation and apoptosis. If C11orf42 stability or function is regulated by proteasomal degradation, this inhibitor could affect its activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A tyrosine kinase inhibitor that can impede various signaling pathways including Src family kinases. If C11orf42 is associated with these pathways, its activity could be indirectly inhibited. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
A selective inhibitor for certain tyrosine kinases like BCR-ABL and c-Kit. If C11orf42 activity is linked to signaling pathways involving these kinases, Imatinib could indirectly inhibit its function. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
An AKT inhibitor that blocks the activation of AKT, leading to reduced survival and proliferation signals. If C11orf42 is an AKT pathway component, its activity could be indirectly reduced. | ||||||