Date published: 2025-12-19

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Btk Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of Btk monoclonal antibodies for investigating Bruton's tyrosine kinase (Btk) signaling pathways. Btk Antibodies are available for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Bruton's tyrosine kinase plays a critical role in B-cell development and function, making it essential for the immune response. Dysregulation of Btk has been implicated in several hematological malignancies and autoimmune diseases, highlighting its importance as a therapeutic target. Btk monoclonal antibodies enable detailed examination of B-cell signaling pathways and their role in disease progression. Researchers can explore Btk expression patterns across different cell types and tissues to better understand its biological functions. Advanced visualization techniques using fluorescent conjugates allow for precise localization and quantification of Btk in cellular compartments. Multiple validated formats are available, including conjugates with horseradish peroxidase (HRP), phycoerythrin (PE), and fluorescein isothiocyanate (FITC). Santa Cruz Biotechnology monoclonal antibodies for Btk research support scientists worldwide in advancing our understanding of immune system regulation and disease mechanisms.

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Btk Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Btk Antibody (E-9)

sc-28387mouse IgG1 λ1-391 (m)WB, IP, IF, ELISAm, r, h
16
(9)

Btk Antibody (7F12H4)

sc-81159mouse IgG1 κ459-659 (h)WB, IP, IF, IHC(P)m, r, h
7
(3)

Btk Antibody (10d11)

sc-81170mouse IgG1 κ1-175 (h)WB, IPm, r, h

new

(2)

Btk Antibody (DFW)

sc-81736mouse IgG1 κ212-275 (h)WB, IP, FCMm, r, h

new

(1)

Btk Antibody (DFS)

sc-81735mouse IgG2a κ212-275 (h)WB, IP, FCMm, r, h
6
(2)

Btk CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Btk CRISPR/Cas9 KO Plasmid (h)

sc-400603hGene KnockoutGFP0
(0)

Btk HDR Plasmid (h)

sc-400603-HDRhHomology Directed RepairPuromycin0
(0)

Btk Double Nickase Plasmid (h)

sc-400603-NIChGene KnockoutPuromycin0
(0)

Btk Double Nickase Plasmid (h2)

sc-400603-NIC-2hGene KnockoutPuromycin0
(0)

Btk CRISPR/Cas9 KO Plasmid (m)

sc-419376mGene KnockoutGFP0
(0)

Btk HDR Plasmid (m)

sc-419376-HDRmHomology Directed RepairPuromycin0
(0)

Btk Double Nickase Plasmid (m)

sc-419376-NICmGene KnockoutPuromycin0
(0)

Btk Double Nickase Plasmid (m2)

sc-419376-NIC-2mGene KnockoutPuromycin0
(0)

Btk CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Btk CRISPR Activation Plasmid (h)

sc-400603-ACThGene ActivationPuro, Blast, Hygro0
(0)

Btk CRISPR Activation Plasmid (h2)

sc-400603-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Btk Lentiviral Activation Particles (h)

sc-400603-LAChGene ActivationPuro, Blast, Hygro0
(0)

Btk Lentiviral Activation Particles (h2)

sc-400603-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Btk CRISPR Activation Plasmid (m)

sc-419376-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Btk CRISPR Activation Plasmid (m2)

sc-419376-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Btk Lentiviral Activation Particles (m)

sc-419376-LACmGene ActivationPuro, Blast, Hygro0
(0)

Btk Lentiviral Activation Particles (m2)

sc-419376-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Btk siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Btk siRNA (h)

sc-29841hGene SilencingN/A
4
(0)

Btk shRNA Plasmid (h)

sc-29841-SHhGene SilencingPuromycin
4
(0)

Btk shRNA (h) Lentiviral Particles

sc-29841-VhGene SilencingPuromycin
4
(0)

Btk siRNA (m)

sc-29842mGene SilencingN/A0
(0)

Btk shRNA Plasmid (m)

sc-29842-SHmGene SilencingPuromycin0
(0)

Btk shRNA (m) Lentiviral Particles

sc-29842-VmGene SilencingPuromycin0
(0)