BTC Activators are a specialized class of chemical compounds designed to modulate the activity of betacellulin (BTC), a member of the epidermal growth factor (EGF) family of proteins. BTC is a polypeptide growth factor that plays a crucial role in regulating cellular proliferation, differentiation, and survival by binding to its receptor, the EGF receptor (EGFR). EGFR activation triggers a cascade of intracellular signaling pathways, influencing various cellular processes, including development, tissue repair, and maintenance of normal physiological functions. BTC, specifically, is notable for its ability to activate EGFR and initiate downstream signaling events.
BTC Activators are compounds engineered to interact with BTC and modify its binding affinity or its ability to activate EGFR. These activators can either enhance or inhibit BTC's effects, depending on their chemical structure and mode of action. By targeting BTC, these compounds provide researchers with a tool to investigate the intricacies of BTC-EGFR signaling, helping to elucidate the precise mechanisms by which this growth factor regulates cellular responses. The study of BTC Activators is essential for advancing our understanding of the molecular pathways associated with EGFR activation and its involvement in various biological processes. Researchers continue to explore the mechanisms of BTC activation and its implications in cellular physiology, offering insights into the complex network of growth factor signaling pathways and their roles in tissue development and homeostasis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
A tyrosine kinase inhibitor specific for EGFR. It can affect BTC activity indirectly by modulating EGFR downstream signaling. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Another EGFR inhibitor, it can modulate BTC signaling indirectly by targeting the EGFR pathway. | ||||||
Pelitinib | 257933-82-7 | sc-208155 | 5 mg | $430.00 | ||
An irreversible EGFR inhibitor, influencing BTC activity indirectly through the EGFR pathway. | ||||||
Canertinib | 267243-28-7 | sc-207397 | 10 mg | $260.00 | 3 | |
An irreversible pan-ErbB inhibitor, which can affect BTC signaling by targeting multiple ErbB receptors. | ||||||
Afatinib | 439081-18-2 | sc-364398 sc-364398A | 5 mg 10 mg | $114.00 $198.00 | 13 | |
A potent irreversible EGFR family inhibitor, it can indirectly influence BTC activity by altering EGFR/ErbB4 signaling. | ||||||
Neratinib | 698387-09-6 | sc-364549 sc-364549A sc-364549B sc-364549C sc-364549D | 5 mg 25 mg 100 mg 500 mg 1 g | $92.00 $214.00 $383.00 $755.00 $1250.00 | 4 | |
An irreversible inhibitor of EGFR, HER2, and ErbB4, impacting BTC activity by modulating these pathways. | ||||||
TAK 165 | 366017-09-6 | sc-361372 sc-361372A | 10 mg 50 mg | $139.00 $781.00 | ||
An inhibitor of HER2/ErbB2, with potential indirect effects on BTC signaling via the ErbB pathway. | ||||||