BRP44L Activators
BRP44L activators refer to a group of compounds that engage with the protein BRP44L, also known as Brain Protein 44-Like, to modulate its activity within cellular systems. BRP44L is a protein implicated in various intracellular processes, including mitochondrial function and energy metabolism. The exact biological function of BRP44L is not fully elucidated, but it is thought to have a role in the regulation of mitochondrial dynamics, which is crucial for maintaining cellular energy balance and metabolic homeostasis.
Activators of BRP44L can function through direct or indirect mechanisms. Direct activators may bind to specific domains of the BRP44L protein, altering its conformation to enhance its activity or interaction with other proteins within the mitochondrial matrix or membrane. This can lead to a cascade of effects that boost mitochondrial efficiency and the cell's energetic output. For instance, direct activators could stabilize the active form of BRP44L or enhance its binding affinity for other mitochondrial proteins, promoting processes such as oxidative phosphorylation or mitochondrial biogenesis.
On the other hand, indirect BRP44L activators work by modulating the signaling pathways that regulate BRP44L expression or activity. These could be compounds that influence transcription factors responsible for the gene expression of BRP44L or molecules that affect post-translational modifications of the protein, thereby impacting its function. For example, indirect activators might increase the phosphorylation of BRP44L, which could affect its localization within the cell or its ability to interact with other mitochondrial proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
As the main substrate for MPC1, increasing concentrations of pyruvate could indirectly increase the activity of MPC1 as more pyruvate is available for transport into the mitochondria. | ||||||
Sodium dichloroacetate | 2156-56-1 | sc-203275 sc-203275A | 10 g 50 g | $54.00 $205.00 | 6 | |
DCA is known to stimulate pyruvate dehydrogenase (PDH), an enzyme that increases pyruvate consumption within the mitochondria. By doing so, it might indirectly increase MPC1 activity by increasing the mitochondrial demand for pyruvate. | ||||||
α-Cyano-4-hydroxycinnamic acid | 28166-41-8 | sc-254923 | 2 g | $42.00 | 2 | |
Although historically known as an inhibitor of the MPC, its presence might cause cells to upregulate MPC1 as a compensatory mechanism. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Commonly used as an antidiabetic drug, metformin has been suggested to influence MPC activity, although its direct effect on MPC1 activation is not entirely clear. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
These are peroxisome proliferator-activated receptor gamma (PPARγ) agonists and have been shown to influence multiple aspects of cellular metabolism. By modulating metabolic pathways, they may indirectly impact MPC1 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Known to impact mitochondrial function and has shown potential in regulating cellular metabolism. Its effect could extend to MPC1 function indirectly. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
A known activator of AMP-activated protein kinase (AMPK), which can influence cellular metabolism and might indirectly modulate MPC1 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A compound that influences several metabolic pathways and has been touted for its potential benefits in conditions like diabetes. By modulating cellular metabolism, it may impact MPC1 function. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
A component of the electron transport chain in mitochondria. By supporting oxidative phosphorylation, there might be an indirect effect on pyruvate transport and MPC1. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
A precursor for NAD+, it plays a role in many metabolic reactions and might indirectly influence MPC1. | ||||||