BRCC2 Activators

BRCC2 can engage in diverse mechanisms to enhance its role in the maintenance of genomic stability. Resveratrol, for instance, activates sirtuins such as SIRT1, which are implicated in the longevity and DNA repair pathways. The activation of SIRT1 by resveratrol can lead to the enhancement of DNA repair mechanisms where BRCC2 is a key player. Similarly, Spermidine can initiate autophagy, a cellular recycling process that clears damaged cellular components, thereby facilitating a more efficient DNA repair process that BRCC2 is involved in. AMP-activated protein kinase (AMPK) activators, such as AICAR and metformin, can also play a role in the activation of BRCC2 by triggering AMPK, which then influences various downstream targets involved in DNA repair.

Compounds like Curcumin, Epigallocatechin gallate (EGCG), and Quercetin can modulate different signaling pathways and kinase activities, supporting the role of BRCC2 in DNA damage response. Curcumin, for example, can modulate the activity of proteins associated with DNA repair, which may affect BRCC2 function. EGCG, a catechin found in green tea, influences several signaling pathways, including those related to DNA repair, and can support BRCC2 activity in repairing DNA damage. Sulforaphane, by activating the NRF2 pathway, helps to regulate the expression of antioxidant proteins that guard against oxidative damage, indirectly enhancing BRCC2's function in repairing DNA damage. NAD+ precursors like Nicotinamide mononucleotide (NMN) can increase the levels of NAD+, necessary for sirtuins and PARPs, which are involved in DNA repair, thus potentially enhancing BRCC2 activation. SRT1720, as a specific activator of SIRT1, could lead to activation of DNA repair functions where BRCC2 is involved. Piperlongumine, by increasing intracellular reactive oxygen species, can enhance DNA damage responses that may activate BRCC2's role in the DNA repair pathways. These chemical activators, through various cellular mechanisms, can support the activation of BRCC2, contributing to its role in DNA repair and genomic stability.