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BLU Inhibitors

Chemical inhibitors of BLU can exert their inhibitory action through interference with microtubule dynamics and related signaling pathways that are critical for BLU's functional role in cellular structure and organization. Imatinib, Nilotinib, and Dasatinib are tyrosine kinase inhibitors that target c-Abl kinase, a protein involved in cytoskeletal remodeling. Since BLU is associated with microtubule organization, the inhibition of c-Abl kinase by these compounds can impair the functions of BLU within the cell. The stabilization of microtubules by Paclitaxel (Taxol) and Peloruside A, and the opposing action of microtubule destabilization by Nocodazole, Vincristine, Colchicine, Vinblastine, and Podophyllotoxin, all serve to disrupt the delicate balance of microtubule dynamics that BLU is involved in. Paclitaxel and Peloruside A, by preventing microtubule disassembly, and Nocodazole and Colchicine, by inhibiting microtubule polymerization, can indirectly inhibit BLU by either stabilizing or destabilizing the microtubule structures and thus affecting BLU's ability to regulate these structures. Furthermore, Eribulin's specific inhibition of microtubule growth without affecting the shortening phase presents a unique mechanism by which BLU's function could be indirectly inhibited, as BLU's activity is tied to the proper formation and maintenance of microtubules within the cell. Laulimalide, similar to Paclitaxel and Peloruside A, stabilizes microtubules but does so through a different binding site on the microtubule structure, offering another route through which the function of BLU can be impeded. By altering the dynamics of microtubule assembly and disassembly, all these chemicals can influence the cellular framework and processes that are necessary for the proper functioning of BLU, leading to its functional inhibition.

Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Imatinib	152459-95-5	sc-267106 sc-267106A sc-267106B	10 mg 100 mg 1 g	$25.00 $117.00 $209.00	27	(1)
Imatinib inhibits the c-Abl tyrosine kinase which is implicated in cytoskeletal remodeling processes. As BLU is involved in cytoplasmic microtubule dynamics, inhibition of c-Abl can impair the proper functioning of BLU in cellular structural maintenance.
Nilotinib	641571-10-0	sc-202245 sc-202245A	10 mg 25 mg	$205.00 $405.00	9	(1)
Nilotinib, another inhibitor of the c-Abl kinase, could disrupt the signaling required for BLU's role in microtubule organization, leading to functional inhibition of BLU's activity in this context.
Dasatinib	302962-49-8	sc-358114 sc-358114A	25 mg 1 g	$47.00 $145.00	51	(1)
Dasatinib targets multiple tyrosine kinases including c-Abl. By inhibiting these kinases, it could indirectly affect BLU by disrupting the signaling pathways BLU relies on for proper function in cell structure regulation.
Taxol	33069-62-4	sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C	1 mg 5 mg 25 mg 100 mg 250 mg 1 g	$40.00 $73.00 $217.00 $242.00 $724.00 $1196.00	39	(2)
Paclitaxel stabilizes microtubules and prevents their disassembly. Since BLU is associated with microtubule dynamics, paclitaxel's effect on microtubules can indirectly inhibit the proper functional activity of BLU in microtubule organization.
Nocodazole	31430-18-9	sc-3518B sc-3518 sc-3518C sc-3518A	5 mg 10 mg 25 mg 50 mg	$58.00 $83.00 $140.00 $242.00	38	(2)
Nocodazole disrupts microtubules by binding to β-tubulin and inhibiting polymerization. This can functionally inhibit BLU by impeding the microtubule-related processes BLU is implicated in.
Colchicine	64-86-8	sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E	1 g 5 g 50 g 100 g 500 g 1 kg	$98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00	3	(2)
Colchicine binds to tubulin and inhibits its polymerization into microtubules. This action can inhibit BLU by preventing the assembly of microtubules, thereby affecting BLU's functional role in microtubule dynamics.
Vinblastine	865-21-4	sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D	10 mg 50 mg 100 mg 500 mg 1 g	$100.00 $230.00 $450.00 $1715.00 $2900.00	4	(0)
Vinblastine disrupts microtubule assembly by binding to tubulin. By doing so, it could functionally inhibit BLU by affecting the microtubule architecture that is essential for BLU's activity.
Eribulin	253128-41-5	sc-507547	5 mg	$865.00		(0)
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase. This selective inhibition of microtubule dynamics can functionally inhibit BLU by altering the cellular framework with which it interacts.
Podophyllotoxin	518-28-5	sc-204853	100 mg	$82.00	1	(1)
Podophyllotoxin binds to tubulin and inhibits its polymerization. This action can indirectly inhibit BLU by destabilizing the microtubule structures that are crucial for BLU's functional role in cells.
Laulimalide	115268-43-4	sc-507261	100 µg	$200.00		(0)
Laulimalide also stabilizes microtubules and can inhibit the disassembly of microtubules. This can inhibit BLU by disturbing the natural dynamics of microtubules that BLU requires for its cellular functions.

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