BJ-TSA-9 Activators

Family with sequence similarity 83, member A (FAM83A) is a protein encoded by the FAM83A gene in humans. It is part of the FAM83 protein family, characterized by a conserved domain of unknown function (DUF1669) at the N-terminus. The FAM83 family members, including FAM83A, are known to be involved in important cellular processes, though the precise mechanisms by which they function are not yet fully elucidated.

FAM83A is notably expressed in epithelial cells and has been implicated in the regulation of cell signaling pathways that are critical for cell proliferation, differentiation, and survival. It has gained attention due to its overexpression in various types of cancers, including breast, lung, and ovarian cancer, suggesting a potential role in tumorigenesis. In cancer cells, FAM83A may contribute to oncogenic signaling by interacting with and affecting components of key pathways such as the PI3K/AKT/mTOR and RAS/MAPK pathways, which are known for their involvement in promoting cell growth and preventing apoptosis.Further studies have indicated that FAM83A may serve as a biomarker for cancer prognosis and could be a target for intervention.