biotinidase Inhibitors
Biotinidase Inhibitors pertain to a category of chemical compounds designed to interact with and hinder the activity of the biotinidase enzyme. Biotinidase is a crucial enzyme in the human body responsible for recycling biotin, also known as vitamin B7, which plays an essential role in various biochemical reactions. Biotinidase enables the release of biotin from biotin-containing proteins and assists in its reutilization. Biotin itself is essential for several enzymatic carboxylation reactions involved in fatty acid synthesis, amino acid metabolism, and other vital cellular processes. Inhibitors of biotinidase are crafted to interfere with the enzyme's function, leading to a reduction in the recycling and availability of biotin for these critical biochemical reactions.
Structurally, biotinidase inhibitors are designed to engage specific sites or regions on the biotinidase enzyme, thereby disrupting its catalytic activity. This interference can affect the enzyme's ability to cleave biotin from biocytin, a biotin-containing peptide, which in turn may lead to a decreased supply of free biotin for use in metabolic pathways. The study of biotinidase inhibitors and their interactions with the enzyme is valuable for researchers seeking to understand the regulation of biotin homeostasis and its broader implications in cellular metabolism.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
A biotin derivative that could potentially act as a competitive inhibitor for the enzyme. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Known to inhibit dihydrofolate reductase, but also affects other enzymes. Its broader impact on metabolic pathways might indirectly affect biotin-related processes. | ||||||
Azaserine | 115-02-6 | sc-29063 sc-29063A | 50 mg 250 mg | $306.00 $906.00 | 15 | |
A glutamine analog that inhibits various enzymes. It could affect metabolic pathways involving biotin. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Can act as a general metabolic inhibitor affecting numerous enzymes and pathways, potentially including those related to biotin. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Inhibits several enzymes involved in amino acid biosynthesis. Its broader effects could potentially impact biotin-related pathways. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Affects ribonucleotide reductase and could influence DNA replication and repair, potentially having indirect effects on protein expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Affects thymidylate synthase, and its impact on DNA synthesis could indirectly affect various metabolic pathways. | ||||||
6-Diazo-5-oxo-L-norleucine | 157-03-9 | sc-227078 sc-227078A sc-227078B sc-227078C | 5 mg 25 mg 100 mg 250 mg | $82.00 $285.00 $908.00 $2152.00 | ||
Inhibits several glutamine-utilizing enzymes. Given the interconnected nature of metabolic pathways, it might influence biotin-related processes. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $53.00 | ||
Known for its selective toxicity to insulin-producing pancreatic beta cells. Its broader metabolic effects could impact biotin-related processes. | ||||||
Aminopterin | 54-62-6 | sc-202461 | 50 mg | $102.00 | 1 | |
A folic acid antagonist affecting various enzymes. Its broader metabolic effects might influence biotin-dependent processes. | ||||||