Azaserine CAS: 115-02-6
MF: C5H7N3O4
MW: 173.13
A hexosamine biosynthesis inhibitor.

Azaserine (CAS 115-02-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Azaserine is rated 5.0 out of 5 by 3.
5
3
4
0
3
0
2
0
1
0
备用名: AZS; O-Diazoacetyl-L-serine
应用; Azaserine is a hexosamine biosynthesis inhibitor
CAS号码: 115-02-6
纯度: ≥98%
分子量: 173.13
分子式: C5H7N3O4
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Azaserine is an inhibitor of the rate limiting step of the hexosamine biosynthethic pathway (HBP) and an irreversible inhibitor of GGT1 (gamma-Glutamyltranspeptidase). Independent of inhibiting the HBP pathway, azarine studies have demonstrated that it can protect against hyperglycemic endothelial damage through its antioxidant effect. Azarine and acivicin (sc-200498), another GGT inhibitor, bind to GGT at its substrate-binding pocket. The compound has been shown to elevate the SOD-2 (manganese-superoxide dismutase (MnSOD)) protein level as well as inhibit the oxidative stress and the expression of VCAM-1 and ICAM-1 in response to TNFα. Research indicates that azaserine has the potential to be used as a probe for identifying the L-(leucine-favoring) system transporter in human T-lymphocytes.


参考文献

1. Segel, G.B., et al. 1989. J. Biol. Chem. 264: 16399-16402. PMID: 2789219

2. Hull, R.L., et al. 2007. Am. J. Physiol., Cell Physiol. 293: C1586-C1593. PMID: 17804609

3. Wada, K., et al. 2008. J. Mol. Biol. 380: 361-372. PMID: 18555071

4. Rajapakse, A.G., et al. 2009. Am. J. Physiol. Heart Circ. Physiol. 296: H815-H822. PMID: 19136606

5. Hull, R.L. et al. 2007. Am. J. Physiol., Cell Physiol. 293(5): C1586-C1593. PMID: 17804609

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/ml), Slightly soluble in methanol, and absolute alcohol.
保存 :
Store at -20° C
pK值 :
pKa: 8.55, pKb: 8.56 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
VT9625000
运输 :
UN 3462, Class 6.1, Packing group III
PubChem CID :
默克索引 :
14: 899
MDL 号码 :
MFCD00036802
EC号码 :
204-061-6
Beilstein 注册 :
1726602
SMILES :
C([[email protected]@H](C(=O)O)N)O/C(=C/[N+]#N)/[O-]

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

Azaserine (CAS 115-02-6)  产品相关文献索引

看其他用户如何应用Azaserine (CAS 115-02-6).点击进入浏览PubMed条目 .

引用1 - 1015

PMID: # 23967162  O'Rourke, RW. et al. 2013. PloS one. 8: e71165.

PMID: # 20460427  Riedl, E. et al. 2010. Diabetes. 59: 1984-90.

PMID: # 17804609  Hull, RL. et al. 2007. Am. J. Physiol., Cell Physiol. 293: C1586-C1593.

PMID: # 12562784  Franke, I. et al. 2003. J. Bacteriol. 185: 1161-1166.

PMID: # 11319101  El Alaoui, S. et al. 2001. Appl. Environ. Microbiol. 67: 2202-2207.

PMID: # 11472902  Lindell, D. et al. 2001. Appl. Environ. Microbiol. 67: 3340-3349.

PMID: # 10806247  Vidmar, JJ. et al. 2000. Plant Physiol. 123: 307-318.

PMID: # 10732764  Mäkinen, K. et al. 2000. Br. J. Cancer. 82: 900-904.

PMID: # 16653163  Callies, R. et al. 1992. Plant Physiol. 100: 1584-1586.

PMID: # 6332732  Longnecker, DS. et al. 1984. Environ. Health Perspect. 56: 245-251.

引用1 - 1015
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 115ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话(021) 800-820-8626。 版权 ©, 2007-2021圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。