Date published: 2025-10-19

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Biotin Derivatives

Santa Cruz Biotechnology now offers a broad range of biotin derivatives for use in various applications. Biotin derivatives, which are chemically modified forms of biotin, have become indispensable tools in scientific research due to their strong affinity for streptavidin and avidin proteins. This high-affinity interaction is exploited in a variety of applications, including bioconjugation, labeling, and purification processes. In molecular biology, biotin derivatives are commonly used to label nucleic acids and proteins, facilitating their detection and isolation in experiments such as Western blotting, ELISA, and immunoprecipitation. These derivatives also play a critical role in developing biotin-streptavidin systems for affinity purification, which are essential for purifying proteins, nucleic acids, and other bioconjugates with high specificity and efficiency. In cell biology, biotinylated molecules are used to study cell surface interactions, receptor binding, and signal transduction pathways, providing insights into cellular mechanisms and functions. Environmental scientists utilize biotin derivatives in biosensor technologies to detect and quantify pollutants and other environmental contaminants, contributing to environmental monitoring and protection efforts. Additionally, in nanotechnology and materials science, biotin derivatives are employed to functionalize nanoparticles and other materials, enabling the development of advanced diagnostic tools and smart materials with tailored properties. By offering a diverse selection of biotin derivatives, Santa Cruz Biotechnology supports a wide range of scientific endeavors, enabling researchers to select the appropriate derivative for their specific experimental needs. This extensive range of biotin derivatives facilitates innovation and discovery across multiple scientific disciplines, including chemistry, biology, environmental science, and materials science. View detailed information on our available biotin derivatives by clicking on the product name.

Items 81 to 90 of 118 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

N-Boc-Biotinylethylenediamine

225797-46-6sc-391949
100 mg
$360.00
(0)

N-Boc-Biotinylethylenediamine is a versatile biotin derivative characterized by its N-Boc protection and ethylenediamine linkage. This structure enhances its solubility and stability in aqueous environments, facilitating efficient conjugation with target molecules. The biotin moiety allows for strong affinity towards avidin, while the ethylenediamine segment introduces potential for diverse functionalization, enabling tailored interactions in biochemical assays and research applications.

Biocytinamidoethyl Methanethiosulfonate, Trifluroacetic Acid Salt

353754-92-4sc-210922
10 mg
$320.00
(0)

Biocytinamidoethyl Methanethiosulfonate, Trifluoroacetic Acid Salt is a distinctive biotin derivative featuring a methanethiosulfonate group that enables selective thiol-reactive interactions. This compound exhibits unique reactivity profiles, facilitating the formation of stable thioether bonds with biomolecules. Its trifluoroacetic acid salt form enhances solubility and stability, promoting efficient incorporation into various biochemical pathways, while its structural attributes allow for precise modulation of molecular interactions.

Biotinamidocaproate Tobramycin Amide

419573-19-6sc-207360
5 mg
$330.00
(0)

Biotinamidocaproate Tobramycin Amide is a notable biotin derivative characterized by its amide linkage, which enhances its molecular stability and solubility in biological systems. This compound exhibits unique binding affinities, allowing for specific interactions with target proteins through non-covalent forces. Its distinct structural features facilitate selective recognition in biochemical assays, while its caproate chain contributes to hydrophobic interactions, influencing cellular uptake and distribution.

N-Biotinyl-12-aminododecanoyltobramycin Amide

419573-20-9sc-207986
5 mg
$430.00
(0)

N-Biotinyl-12-aminododecanoyltobramycin Amide is a sophisticated biotin derivative distinguished by its elongated aliphatic chain, which promotes enhanced lipophilicity and membrane permeability. The compound's unique amide bond configuration allows for versatile molecular interactions, facilitating specific binding to biomolecules. Its structural design supports effective self-assembly in aqueous environments, potentially influencing aggregation behavior and enhancing its role in biochemical pathways.

N-Biotinylcaproylaminocaproylaminoethyl Methanethiosulfonate

1038749-81-3sc-212138
10 mg
$380.00
(0)

N-Biotinylcaproylaminocaproylaminoethyl Methanethiosulfonate is a specialized biotin derivative characterized by its unique methanethiosulfonate group, which enables selective thiol-reactive properties. This compound exhibits a propensity for forming stable thioether linkages, enhancing its ability to engage in covalent modifications with target molecules. Its distinct hydrophilic and hydrophobic balance facilitates interactions across diverse biological environments, potentially influencing protein labeling and tracking in complex systems.

1,3-Dibenzyldihydro-1H-selenolo[3,4-d]imidazole-2,4-(3H,3aH)dione

1185143-93-4sc-213496
10 mg
$330.00
(0)

1,3-Dibenzyldihydro-1H-selenolo[3,4-d]imidazole-2,4-(3H,3aH)dione is a notable biotin derivative distinguished by its selenium-containing heterocyclic structure. This compound exhibits unique electron-donating properties, facilitating specific interactions with metal ions and enhancing catalytic activity in various reactions. Its dual aromatic and imidazole functionalities contribute to versatile binding modes, allowing for selective recognition of biomolecules and influencing reaction kinetics in complex biochemical pathways.

Atto 520-Biotin

sc-300207
1 mg
$75.00
(0)

Atto 520-Biotin is a specialized biotin derivative known for its fluorescent properties, which enable sensitive detection in various biochemical applications. Its unique structure allows for efficient conjugation to biomolecules, enhancing signal amplification in assays. The compound exhibits strong affinity for biotin-binding proteins, facilitating specific interactions that can be monitored in real-time. Additionally, its photostability ensures reliable performance in dynamic experimental conditions, making it a valuable tool for studying molecular interactions.

Atto 590-Biotin

sc-319835
1 mg
$143.00
(0)

Atto 590-Biotin is a specialized biotin derivative known for its exceptional photostability and strong absorption in the near-infrared region. This compound exhibits a high affinity for biotin-binding proteins, facilitating precise labeling and detection in various biochemical contexts. Its unique structural features enable efficient energy transfer in fluorescence applications, while its low background signal enhances the clarity of imaging techniques, making it ideal for studying complex biological systems.

Atto 565-Biotin

sc-319833
1 mg
$168.00
(0)

Atto 565-Biotin is a distinctive biotin derivative characterized by its vibrant fluorescence and robust stability under diverse experimental conditions. This compound demonstrates a remarkable ability to form stable complexes with avidin and streptavidin, enhancing specificity in biochemical assays. Its unique conjugation properties allow for versatile labeling strategies, while its efficient energy transfer mechanisms contribute to improved signal intensity in detection applications, making it a powerful tool for probing molecular interactions.

Biotinyl Cystamine

128915-82-2sc-210924
sc-210924A
10 mg
50 mg
$320.00
$930.00
1
(0)

Biotinyl Cystamine is a notable biotin derivative distinguished by its dual functionality, featuring both biotin and cystamine moieties. This compound exhibits unique redox properties, facilitating disulfide bond formation and cleavage, which can influence protein interactions and stability. Its ability to engage in specific molecular interactions enhances its role in bioconjugation processes, while its structural flexibility allows for tailored modifications, optimizing reactivity in various biochemical environments.