Date published: 2025-12-5

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Biotin Derivatives

Santa Cruz Biotechnology now offers a broad range of biotin derivatives for use in various applications. Biotin derivatives, which are chemically modified forms of biotin, have become indispensable tools in scientific research due to their strong affinity for streptavidin and avidin proteins. This high-affinity interaction is exploited in a variety of applications, including bioconjugation, labeling, and purification processes. In molecular biology, biotin derivatives are commonly used to label nucleic acids and proteins, facilitating their detection and isolation in experiments such as Western blotting, ELISA, and immunoprecipitation. These derivatives also play a critical role in developing biotin-streptavidin systems for affinity purification, which are essential for purifying proteins, nucleic acids, and other bioconjugates with high specificity and efficiency. In cell biology, biotinylated molecules are used to study cell surface interactions, receptor binding, and signal transduction pathways, providing insights into cellular mechanisms and functions. Environmental scientists utilize biotin derivatives in biosensor technologies to detect and quantify pollutants and other environmental contaminants, contributing to environmental monitoring and protection efforts. Additionally, in nanotechnology and materials science, biotin derivatives are employed to functionalize nanoparticles and other materials, enabling the development of advanced diagnostic tools and smart materials with tailored properties. By offering a diverse selection of biotin derivatives, Santa Cruz Biotechnology supports a wide range of scientific endeavors, enabling researchers to select the appropriate derivative for their specific experimental needs. This extensive range of biotin derivatives facilitates innovation and discovery across multiple scientific disciplines, including chemistry, biology, environmental science, and materials science. View detailed information on our available biotin derivatives by clicking on the product name.

Items 31 to 40 of 118 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

N-Biotinylcaproylaminocaproic Acid

89889-51-0sc-212137
25 mg
$306.00
(0)

N-Biotinylcaproylaminocaproic Acid is a biotin derivative characterized by its unique caproyl and aminocaproic acid components, which promote specific hydrogen bonding and electrostatic interactions. This compound exhibits enhanced solubility in various solvents, facilitating its integration into diverse biochemical environments. Its structure allows for efficient binding to avidin and streptavidin, enabling the exploration of biotin-related pathways and interactions in complex biological matrices.

3-[2-N-(Biotinyl)aminoethyldithio]propanoic Acid

104582-29-8sc-206612A
sc-206612B
sc-206612
10 mg
50 mg
100 mg
$148.00
$235.00
$367.00
(0)

3-[2-N-(Biotinyl)aminoethyldithio]propanoic Acid is a biotin derivative distinguished by its dithioether linkage, which enhances its reactivity and stability in biochemical applications. The presence of the biotin moiety facilitates strong affinity interactions with avidin and streptavidin, while the aminoethyl group allows for versatile conjugation possibilities. This compound's unique structure promotes specific molecular recognition and can influence reaction kinetics in various biochemical assays.

Biotin-[2-(2-pyridyldithio)ethylamide]

112247-65-1sc-210923
100 mg
$388.00
(0)

Biotin-[2-(2-pyridyldithio)ethylamide] is a biotin derivative characterized by its pyridyldithio group, which introduces unique redox properties and enhances its reactivity in thiol-disulfide exchange reactions. This compound exhibits selective binding capabilities, allowing for targeted interactions in biochemical systems. Its structural features facilitate the formation of stable conjugates, influencing molecular recognition and enabling diverse applications in bioconjugation strategies.

Sulpho NHS biotin

119616-38-5sc-258187
100 mg
$262.00
(1)

Sulpho NHS biotin is a biotin derivative distinguished by its sulfonamide group, which enhances solubility and stability in aqueous environments. This compound exhibits a high reactivity profile, particularly in amine coupling reactions, allowing for efficient bioconjugation. Its unique structure promotes specific interactions with biomolecules, facilitating the formation of stable linkages. The presence of the sulfonate moiety also aids in reducing non-specific binding, optimizing its utility in various biochemical assays.

Fluorescein Biotin

134759-22-1sc-214340
5 mg
$121.00
1
(1)

Fluorescein Biotin is a biotin derivative characterized by its fluorescent properties, which enable sensitive detection in various biochemical applications. The compound features a unique conjugated system that enhances its photostability and brightness, making it ideal for visualization. Its structure allows for specific binding interactions with avidin or streptavidin, facilitating targeted labeling. Additionally, the compound's hydrophilic nature promotes solubility, enhancing its performance in diverse experimental conditions.

N-Biotinyl-12-aminododecanoic Acid

135447-73-3sc-212135
5 mg
$210.00
(0)

N-Biotinyl-12-aminododecanoic Acid is a biotin derivative notable for its unique amphiphilic structure, which promotes self-assembly in aqueous environments. This compound exhibits distinct molecular interactions due to its long aliphatic chain, enhancing membrane permeability and facilitating transport across lipid bilayers. Its carboxylic acid functionality allows for versatile coupling reactions, enabling the formation of stable conjugates with various biomolecules, thus expanding its utility in biochemical research.

2-[2-[2-[2-[6-(Biotinylaminohexanoyl]aminoethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid

207971-23-1sc-206353
1 mg
$430.00
(0)

2-[2-[2-[2-[6-(Biotinylaminohexanoyl]aminoethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid is a biotin derivative characterized by its intricate multi-ethoxy linkages, which enhance solubility and reactivity in polar environments. The trifluoromethyl group introduces unique electronic properties, influencing reaction kinetics and selectivity in coupling processes. Its biotin moiety facilitates specific binding interactions, making it a versatile tool for probing molecular pathways.

Sulfosuccinimidyl 3-[[2-(Biotinamido)ethyl] dithio]propionate Sodium Salt

325143-98-4sc-212981A
sc-212981
sc-212981B
sc-212981C
25 mg
100 mg
500 mg
1 g
$175.00
$400.00
$900.00
$1600.00
4
(0)

Sulfosuccinimidyl 3-[[2-(Biotinamido)ethyl]dithio]propionate Sodium Salt is a biotin derivative notable for its dithioether linkage, which enhances stability and reactivity in biochemical applications. The sulfosuccinimidyl group promotes efficient conjugation to target molecules, facilitating specific interactions. Its unique structure allows for selective labeling and tracking of biomolecules, making it an essential component in various biochemical assays and research methodologies.

6-(Biotinylamino)thiocaproic Acid, S-Ethyl Ester

353754-94-6sc-210445
sc-210445A
10 mg
50 mg
$290.00
$1040.00
(0)

6-(Biotinylamino)thiocaproic Acid, S-Ethyl Ester is a biotin derivative characterized by its thiol-reactive properties, enabling it to form stable thioester bonds with various biomolecules. This compound exhibits unique solubility characteristics due to its ethyl ester group, enhancing its compatibility in diverse biochemical environments. Its ability to engage in specific molecular interactions allows for targeted modifications, making it a versatile tool in the study of protein dynamics and interactions.

1,17-Bisbiotinylamino-3,6,9,12,15-pentaoxaheptadecane

440680-87-5sc-206218
25 mg
$280.00
(0)

1,17-Bisbiotinylamino-3,6,9,12,15-pentaoxaheptadecane is a biotin derivative notable for its unique polyether backbone, which enhances solubility and flexibility in aqueous environments. This compound facilitates multivalent interactions due to its dual biotinyl groups, promoting strong binding to avidin or streptavidin. Its structural design allows for efficient molecular recognition and can influence reaction kinetics, making it a valuable component in biochemical assays and studies of molecular assembly.