Date published: 2025-10-19

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Biotin Derivatives

Santa Cruz Biotechnology now offers a broad range of biotin derivatives for use in various applications. Biotin derivatives, which are chemically modified forms of biotin, have become indispensable tools in scientific research due to their strong affinity for streptavidin and avidin proteins. This high-affinity interaction is exploited in a variety of applications, including bioconjugation, labeling, and purification processes. In molecular biology, biotin derivatives are commonly used to label nucleic acids and proteins, facilitating their detection and isolation in experiments such as Western blotting, ELISA, and immunoprecipitation. These derivatives also play a critical role in developing biotin-streptavidin systems for affinity purification, which are essential for purifying proteins, nucleic acids, and other bioconjugates with high specificity and efficiency. In cell biology, biotinylated molecules are used to study cell surface interactions, receptor binding, and signal transduction pathways, providing insights into cellular mechanisms and functions. Environmental scientists utilize biotin derivatives in biosensor technologies to detect and quantify pollutants and other environmental contaminants, contributing to environmental monitoring and protection efforts. Additionally, in nanotechnology and materials science, biotin derivatives are employed to functionalize nanoparticles and other materials, enabling the development of advanced diagnostic tools and smart materials with tailored properties. By offering a diverse selection of biotin derivatives, Santa Cruz Biotechnology supports a wide range of scientific endeavors, enabling researchers to select the appropriate derivative for their specific experimental needs. This extensive range of biotin derivatives facilitates innovation and discovery across multiple scientific disciplines, including chemistry, biology, environmental science, and materials science. View detailed information on our available biotin derivatives by clicking on the product name.

Items 91 to 100 of 118 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1-Biotinylamino-3,6,9-trioxaundecane-11-yl-methanethiosulfonate

sc-213313
10 mg
$360.00
(0)

1-Biotinylamino-3,6,9-trioxaundecane-11-yl-methanethiosulfonate is a distinctive biotin derivative characterized by its unique trioxaundecane backbone, which enhances solubility and stability in aqueous environments. This compound features a methanethiosulfonate group that facilitates selective thiol reactions, promoting efficient bioconjugation. Its structural design allows for versatile interactions with biomolecules, enabling tailored applications in biochemical assays and research.

Sulfo-N-succinimidyl 6-(biotinamido) hexanoate, sodium salt

191671-46-2sc-212980
100 mg
$600.00
(0)

Sulfo-N-succinimidyl 6-(biotinamido) hexanoate, sodium salt is a specialized biotin derivative known for its robust amine-reactive properties. The sulfo-N-succinimidyl group enhances the compound's reactivity towards primary amines, facilitating efficient conjugation to proteins and other biomolecules. Its hexanoate linker provides flexibility, allowing for optimal spatial orientation in binding interactions. This compound's unique design promotes stable biotinylation, crucial for various biochemical applications.

2-{N2-[N6-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6 -aminocaproyl]-N6-(6-biotinamidocaproyl)-L -lysinylamido}] Ethyl 2-Carboxyethyl Disulfide

sc-213718
1 mg
$360.00
(0)

2-{N2-[N6-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-aminocaproyl]-N6-(6-biotinamidocaproyl)-L-lysinylamido}] Ethyl 2-Carboxyethyl Disulfide is a sophisticated biotin derivative characterized by its dual functionality and unique disulfide linkage. The azido group enables selective click chemistry, facilitating targeted modifications. Its biotin moiety ensures strong affinity for avidin or streptavidin, enhancing detection and isolation processes. The ethyl carboxyethyl component contributes to solubility and stability, promoting versatile applications in biochemical research.

2-[N2-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]ethyl Methanethiosulfonate

1356383-18-0sc-213715
1 mg
$388.00
(0)

2-[N2-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]ethyl Methanethiosulfonate is a distinctive biotin derivative featuring a methanethiosulfonate group that enables site-specific conjugation through thiol-reactive chemistry. The azido functionality allows for efficient click reactions, enhancing molecular labeling and tracking. Its biotin component provides robust binding to streptavidin, facilitating purification and detection in complex biological systems. The compound's unique structure promotes stability and reactivity, making it a valuable tool in biochemical assays.

DY-550-biotin

sc-362203
500 µg
$660.00
(0)

DY-550-biotin is a specialized biotin derivative characterized by its unique fluorophore properties, which enable enhanced fluorescence for sensitive detection applications. The compound exhibits strong affinity for streptavidin, ensuring effective bioconjugation. Its distinct molecular architecture allows for versatile interactions with biomolecules, facilitating the study of protein dynamics and cellular processes. The compound's stability under various conditions further enhances its utility in experimental setups.

Photobiotin acetate salt

96087-38-6sc-215717
sc-215717A
1 mg
2 mg
$559.00
$938.00
1
(0)

Photobiotin acetate salt is a distinctive biotin derivative known for its photoreactive properties, which enable covalent bonding upon exposure to light. This compound features a unique structure that facilitates specific interactions with biomolecules, enhancing its utility in probing cellular mechanisms. Its reactivity profile allows for selective labeling and tracking of proteins, making it a valuable tool in biochemical research. Additionally, its solubility characteristics support diverse experimental conditions.

(+)-Biotin-(PEO)3-iodoacetamide

sc-470524
sc-470524A
50 mg
100 mg
$394.00
$464.00
4
(0)

(+)-Biotin-(PEO)3-iodoacetamide is a specialized biotin derivative characterized by its polyethylene oxide (PEO) chain, which enhances solubility and biocompatibility. This compound exhibits unique reactivity through its iodoacetamide group, enabling efficient conjugation to thiol-containing biomolecules. Its distinct molecular architecture promotes specific interactions with proteins, facilitating targeted labeling and analysis in biochemical studies. The PEO segment also contributes to improved stability and reduced non-specific binding in complex biological environments.

1-Biotinylamino-3,6,9-trioxaundecane-11-bromide

1041766-91-9sc-208623
10 mg
$300.00
(1)

1-Biotinylamino-3,6,9-trioxaundecane-11-bromide is a distinctive biotin derivative featuring a trioxaundecane backbone that enhances its solubility and stability in aqueous environments. The bromide moiety introduces unique reactivity, allowing for selective nucleophilic substitution reactions. This compound's structure facilitates strong interactions with avidin and streptavidin, promoting efficient biotinylation in various biochemical applications. Its design supports versatile conjugation strategies, making it a valuable tool for probing molecular interactions.

Acriflavin-Biotin Conjugate

1041387-90-9sc-207259
1 mg
$320.00
(0)

Acriflavin-Biotin Conjugate is a novel biotin derivative characterized by its dual functionality, combining the properties of acriflavin with biotin. This conjugate exhibits unique photophysical properties, enabling specific light-induced reactions. Its structure promotes enhanced binding affinity to biotin-binding proteins, facilitating targeted interactions. The conjugate's distinct electron-donating characteristics may influence reaction kinetics, making it a compelling candidate for exploring complex biochemical pathways.

Biotinamido Poly(ethylene glycol)1000

sc-217764
5 mg
$330.00
(0)

Biotinamido Poly(ethylene glycol)1000 is a versatile biotin derivative characterized by its unique polymeric structure, which enhances solubility and biocompatibility. The PEG component facilitates hydrophilic interactions, promoting effective molecular recognition and binding. This compound exhibits distinct kinetic behavior in conjugation reactions, allowing for tailored modifications in biochemical applications. Its ability to form stable complexes with biomolecules underscores its potential in diverse biochemical contexts.