Bim EL Activators
Bim EL Activators are a collection of chemical compounds that facilitate the enhancement of Bim EL, a pro-apoptotic protein, through various cellular stressors and signaling pathways. Paclitaxel, by stabilizing microtubules and inducing cell cycle arrest, promotes mitotic stress which can subsequently increase the expression of Bim EL. Similarly, the tyrosine kinase inhibitors Sunitinib and Sorafenib impede growth factor signaling, leading to cellular stress and upregulation of Bim EL to trigger apoptosis. The JNK inhibitor SP600125 could enhance Bim EL levels by interrupting negative feedback regulation, while Thapsigargin and Tunicamycin evoke ER stress and the unfolded protein response, both of which are known to increase Bim EL's pro-apoptotic activity. In addition, Staurosporine, through its broad kinase inhibition, and U0126, by targeting the MEK/ERK pathway, disrupt survival signaling, contributing to the apoptotic cascade where Bim EL is upregulatedas a key effector.
Continuing with this trend, Trichostatin A, by inhibiting histone deacetylases, can potentially upregulate the expression of BCL2L11, leading to enhanced levels of Bim EL. Etoposide, as a topoisomerase II inhibitor, causes DNA damage, which activates the intrinsic apoptotic pathway, a process in which Bim EL plays a pivotal role by promoting cell death. Venetoclax, though specifically targeting Bcl-2, indirectly augments the apoptotic function of Bim EL by disabling its antagonistic counterpart, thus allowing Bim EL's pro-apoptotic action to proceed unimpeded. Lastly, Bortezomib induces proteotoxic stress by inhibiting the proteasome, triggering an apoptotic response that includes the upregulation of Bim EL. Each of these activators, through their distinct interactions with various cellular pathways, contribute to the enhancement of Bim EL's function, demonstrating the intricate network of signals that govern the regulation of apoptosis and the role of Bim EL therein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, leading to cell cycle arrest at the G2/M phase. This can lead to an increase in Bim EL expression as a pro-apoptotic response to mitotic stress. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib is a tyrosine kinase inhibitor that blocks the activity of multiple receptor tyrosine kinases, including VEGFR and PDGFR. This inhibition can lead to cellular stress and potentially upregulate pro-apoptotic proteins like Bim EL. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib inhibits several tyrosine protein kinases, such as VEGFR and PDGFR, and the Raf kinases. This leads to a blockade of the RAF/MEK/ERK signaling pathway, which can result in the induction of apoptosis mediated in part by the upregulation of Bim EL. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Inhibition of JNK can disrupt negative feedback loops, potentially leading to the upregulation of pro-apoptotic proteins like Bim EL. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump inhibitor that leads to an increase in cytosolic calcium levels. Elevated calcium can induce apoptosis, where Bim EL plays a crucial role. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, causing ER stress and the unfolded protein response, which can result in apoptosis and upregulation of pro-apoptotic proteins such as Bim EL. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. This broad kinase inhibition can induce apoptosis, during which Bim EL is upregulated as part of the intrinsic pathway of apoptosis. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which interrupts the MAPK/ERK pathway. Inhibition of this pathway can lead to apoptosis and subsequent upregulation of pro-apoptotic proteins including Bim EL. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can modulate gene expression, potentially leading to the increased expression of pro-apoptotic genes such as BCL2L11 encoding Bim EL. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that induces DNA damage. This damage can lead to apoptosis through the intrinsic pathway, which involves the upregulation of Bim EL. | ||||||