β′-COP Activators
β′-COP activators are a specialized category of chemicals that have the capability to modulate the activity of the β′-COP protein, which is a subunit of the COPI coatomer complex involved in mediating retrograde transport within cells from the Golgi back to the endoplasmic reticulum, as well as within the Golgi cisternae. The COPI complex is critical for maintaining cellular homeostasis by ensuring the proper trafficking of proteins and lipids.
Direct activators of β′-COP would likely interact with the protein in a manner that enhances its ability to bind to membranes or to other subunits within the COPI complex. By stabilizing the complex or by promoting the assembly of COPI vesicles, these activators could increase the efficiency of vesicle formation and cargo selection. This direct binding could also confer a conformational change that optimizes the protein's function. Indirect activators may function by upregulating the expression of genes encoding β′-COP or by stabilizing its mRNA, thus leading to an increased concentration of the protein within the cell. Alternatively, they might influence the post-translational modification of β′-COP, such as phosphorylation, which can have consequences for its activity and interactions within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
A tyrosine kinase inhibitor which can impact EGFR trafficking and indirectly influence COPI-mediated processes, potentially affecting COPB2 function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
This ionophore can disrupt Golgi function, thereby influencing processes that involve COPI-coated vesicles and, by extension, COPB2. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
As a microtubule depolymerizer, it can affect vesicle transport, potentially impacting COPB2-related processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylyl cyclase, raising cAMP levels, and potentially impacting COPI-coated vesicle formation or function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases known to affect vesicle trafficking, and can thus potentially influence COPB2 function. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
As a beta-adrenergic antagonist, it has been shown to affect protein trafficking and could indirectly impact COPB2 activity. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
This compound inhibits the GTPase activity of dynamin, which can affect vesicle scission events, potentially influencing processes involving COPB2. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
A compound that binds to actin monomers, preventing polymerization. This can impact vesicle trafficking and may affect COPB2's role in such processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3 kinase inhibitor. PI3 kinase can influence vesicle trafficking, and its inhibition might indirectly affect COPB2 functions. | ||||||