Tyrphostin AG 1478 (CAS 175178-82-2)

État Physique :

Solid

Solubilité :

Soluble in DMSO (10 mg/ml).

Stockage :

Store at -20° C

Point de fusion :

184.63° C (Predicted)

Point d'Ébullition :

~458.5° C at 760 mmHg (Predicted)

Densité :

~1.3 g/cm³ (Predicted)

Indice de Réfraction :

n²⁰_D 1.67

IC50 :

epidermal growth factor receptor kinase : IC₅₀ = 3 nM; HER2-neu: IC₅₀ = >100 µM; platelet-derived growth factor receptor kinase: IC₅₀ = >100 µM; rat brain Kv1.5 potassium channels : IC₅₀ = 9.8 µM (rat); leiomyoma cell: IC₅₀ = 5.6 µM; myometrium cell : IC₅₀ = 5.7 µM; Epidermal growth factor receptor erbB1: IC₅₀ = 173 nM (human); Epidermal growth factor receptor erbB1: IC₅₀ = 30 nM (human); MCF7 (Breast carcinoma cells): IC₅₀ = 1982 nM (human); Epidermal growth factor receptor erbB1: IC₅₀ = 1.26 nM (human); MCF10 (Normal breast epithelial cells): IC₅₀ = 173 nM (human); Tyrosine-protein kinase LCK: IC₅₀ = 5000 nM (human); Epidermal growth factor receptor erbB1: IC₅₀ = 0.8 nM (human); Protein kinase C alpha: IC₅₀ = >100000 nM (human); Epidermal growth factor receptor erbB1: IC₅₀ = 5 nM (human); NIH3T3 (Fibroblasts): IC₅₀ = 28600 nM (Mus musculus); Fructose-1,6-bisphosphatase: IC₅₀ = >10000 nM (Rattus norvegicus); Oryctolagus cuniculus: IC₅₀ = >10000 nM;

WGK Allemagne :

3

PubChem CID :

Numéro MDL :

MFCD00270914

SMILES :

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC