Date published: 2025-12-20

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β-defensin 128 Inhibitors

β-defensin 128 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of β-defensin 128, a small, cationic, antimicrobial peptide. β-defensins are a subset of the defensin family, known for their broad-spectrum antimicrobial properties, and play a critical role in the innate immune system of many organisms. β-defensin 128, in particular, is notable for its unique structure, which consists of a characteristic β-sheet stabilized by disulfide bonds. These bonds confer stability to the molecule, even in harsh environmental conditions, allowing β-defensin 128 to effectively interact with microbial membranes. The inhibitors of this defensin aim to disrupt its structural integrity or interfere with its interaction with microbial cell surfaces, thereby modulating its function. These inhibitors are often designed to bind specifically to key residues in the β-defensin 128 molecule, altering its overall activity without affecting other members of the defensin family.

From a chemical perspective, β-defensin 128 inhibitors are typically small molecules or peptides that have a high affinity for specific regions of the β-defensin molecule. These regions often include the binding sites critical for its antimicrobial function, such as the positively charged areas that interact with the negatively charged components of microbial membranes. By blocking these interaction sites, inhibitors can prevent β-defensin 128 from effectively attaching to and permeabilizing the microbial cell wall. Additionally, the inhibitors may work by altering the conformation of β-defensin 128, leading to a reduction in its structural stability or its ability to form the characteristic β-sheet configuration. Some inhibitors also interact with metal ions or cofactors that are essential for β-defensin 128's stability and function. The design of these inhibitors requires a deep understanding of the protein's three-dimensional structure and molecular dynamics, often relying on advanced techniques such as X-ray crystallography or molecular modeling.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Zinc

7440-66-6sc-213177
100 g
$47.00
(0)

Zinc ions can stabilize the structure of defensins, enhancing their ability to interact with microbial membranes, leading to increased activity.

L-Arginine

74-79-3sc-391657B
sc-391657
sc-391657A
sc-391657C
sc-391657D
5 g
25 g
100 g
500 g
1 kg
$20.00
$30.00
$60.00
$215.00
$345.00
2
(0)

As a positive charge donor, arginine can enhance the binding of defensins to negatively charged microbial membranes.

Magnesium chloride

7786-30-3sc-255260C
sc-255260B
sc-255260
sc-255260A
10 g
25 g
100 g
500 g
$27.00
$34.00
$47.00
$123.00
2
(1)

Magnesium can be a cofactor in many enzymatic reactions, potentially enhancing the antimicrobial function of defensins.

Calcium chloride anhydrous

10043-52-4sc-207392
sc-207392A
100 g
500 g
$65.00
$262.00
1
(1)

Calcium ions might stabilize defensin structure, promoting oligomerization essential for microbial membrane disruption.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Histone deacetylase inhibitor that can lead to chromatin remodeling, potentially enhancing expression and activity of antimicrobial proteins.

Glycyrrhizic acid

1405-86-3sc-279186
sc-279186A
1 g
25 g
$56.00
$326.00
7
(0)

By modulating immune responses, glycyrrhizin could increase expression of antimicrobial peptides like defensins.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

It is known to upregulate the expression of defensin peptides in human cells, thereby potentially enhancing the activity of defensin beta 128.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium impacts glycogen synthase kinase 3 (GSK-3) activity, which could lead to enhanced expression of antimicrobial peptides.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin can modulate NF-kB pathway, potentially leading to increased expression of immune-related proteins including defensins.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

It can activate SIRT1 which is involved in the regulation of immune function, possibly enhancing defensin activity.