Bcl-7b Activators
Bcl-7b activators represent a diverse array of chemical entities that share a common goal: boosting Bcl-7b's pivotal role in promoting cellular survival and inhibiting apoptosis. These molecules act on a variety of signaling pathways that intricately link to Bcl-7b's regulatory functions. For instance, PMA and Forskolin enhance Bcl-7b activity by activating PKC and elevating cAMP levels, respectively, both processes leading to the phosphorylation of key proteins that support cell survival, a domain where Bcl-7b is crucial. Compounds like retinoic acid and Thapsigargin also contribute by altering gene expression and disrupting calcium signaling, respectively-each vital for cell growth and survival regulation. Specifically, retinoic acid engages with nuclear receptors to possibly upregulate genes that control Bcl-7b, thus amplifying its anti-apoptotic actions, while Thapsigargin interferes with calcium equilibrium, setting off a series of signaling events that reinforce Bcl-7b-dependent survival pathways.
The influence of Bcl-7b activators extends into the realm of epigenetics with agents such as Trichostatin A and SAHA (Vorinostat or Suberoylanilide Hydroxamic Acid) that indirectly augment Bcl-7b's function by modifying the chromatin architecture, thereby promoting the expression of genes tied to survival mechanisms. Altering the epigenetic framework can thus prime the cellular environment for expressing Bcl-7b and related survival pathways more robustly. Other molecules like BAY 11-7082 and PD98059 specifically target NF-κB and MAPK/ERK pathway kinases, influencing Bcl-7b expression and activity, and potentially tipping the scales in favor of cell survival over apoptosis. Even inhibitors such as LY294002, which acts on the PI3K/AKT pathway-a key player in cell survival and proliferation-may, within the complex cellular milieu, instigate a compensatory upregulation of Bcl-7b's anti-apoptotic functions through pathway crosstalk.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which then can influence the phosphorylation state of numerous substrates involved in cell signaling. Activation of PKC has been associated with the regulation of apoptosis and cell survival, processes in which Bcl-7b is implicated. Thus, PMA could enhance Bcl-7b function by promoting survival pathways that Bcl-7b is part of. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcineurin. Calcineurin dephosphorylates NFAT, a transcription factor that can enhance the expression of genes linked to cell survival and apoptosis. Through this mechanism, ionomycin could indirectly enhance the functional activity of Bcl-7b by promoting the cellular processes that Bcl-7b is involved with. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that increases cAMP levels, which activates PKA. This activation could lead to the phosphorylation of transcription factors that enhance the expression of survival genes within the pathways Bcl-7b functions, therefore potentially enhancing the activity of Bcl-7b by bolstering these survival pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to its receptors, which can modulate the transcription of genes, including those that may involve Bcl-7b's function. By influencing gene expression in this way, retinoic acid could augment the activity of Bcl-7b by enhancing signaling pathways that promote cell survival, where Bcl-7b plays a role. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, which can lead to a relaxed chromatin structure and increased transcription of genes in pathways that Bcl-7b is involved with. By doing so, it could indirectly enhance Bcl-7b's functional activity by increasing expression of survival pathways that Bcl-7b functions to support. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferase, potentially leading to hypomethylation of DNA and activation of genes. This could result in the upregulation of survival pathways that Bcl-7b is a part of, thereby indirectly enhancing Bcl-7b's activity by promoting the functional pathways that it supports. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium storage and enhances cytosolic calcium levels, which could activate signaling pathways involving Bcl-7b, thereby potentially enhancing its functional activity in promoting cell survival and inhibiting apoptosis. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA inhibits histone deacetylases, leading to an open chromatin state and potentially increased expression of genes in the pathways where Bcl-7b operates, possibly enhancing the functional activity of Bcl-7b by upregulating the survival pathways it is involved in. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 irreversibly inhibits NF-κB activation, which may result in the alteration of gene expression patterns including those related to Bcl-7b's function, thereby enhancing the activity of Bcl-7b in the context of cell survival and apoptosis pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor, which could lead to the modulation of the MAPK/ERK pathway, a pathway known to influence apoptosis and survival where Bcl-7b may be involved, thus potentially enhancing the activity of Bcl-7b through these interconnected pathways. | ||||||