BC049807 Inhibitors
Chemical inhibitors of zinc finger protein 948 employ various mechanisms to modulate the activity of this protein by altering its phosphorylation state. Chelerythrine and GF109203X, for instance, both target protein kinase C (PKC), a key enzyme responsible for the phosphorylation of many proteins, including zinc finger protein 948. By inhibiting PKC, these chemicals can decrease the phosphorylation and subsequent activation of zinc finger protein 948. Similarly, Bisindolylmaleimide I also inhibits PKC, leading to reduced phosphorylation and inhibition of the functional activity of this protein. Staurosporine, a broad-spectrum protein kinase inhibitor, can diminish the phosphorylation levels of a wide range of proteins, thereby including zinc finger protein 948 among those whose activity is inhibited.
In addition to PKC inhibitors, other chemicals intervene in different signaling pathways to inhibit the phosphorylation of zinc finger protein 948. PD98059 and U0126 both specifically inhibit the MEK1/2, which are upstream activators of extracellular signal-regulated kinases (ERKs). By blocking this pathway, these inhibitors prevent the activation of ERKs and subsequently reduce the phosphorylation of proteins like zinc finger protein 948. SB203580 and SP600125 take a similar approach but in different pathways; SB203580 selectively inhibits p38 MAP kinase, while SP600125 targets c-Jun N-terminal kinase (JNK), both of which are enzymes that can influence the phosphorylation state of zinc finger proteins. LY294002 and Wortmannin are phosphoinositide 3-kinase (PI3K) inhibitors that decrease the activation of downstream signaling targets, which includes proteins like zinc finger protein 948. Rapamycin, which inhibits the mammalian target of rapamycin (mTOR), leads to reduced protein synthesis and can indirectly inhibit the functional activity of zinc finger protein 948. Lastly, SL327, by selectively inhibiting MEK1/2, impedes the MEK/ERK signaling pathway, culminating in the inhibition of phosphorylation and activity of zinc finger protein 948. Each of these chemicals, through their distinct mechanisms, contribute to the modulation of the phosphorylation state and functional activity of zinc finger protein 948.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine inhibits protein kinase C (PKC), which is involved in the phosphorylation of many proteins, including zinc finger proteins like zinc finger protein 948. By inhibiting PKC, chelerythrine can decrease the phosphorylation of zinc finger protein 948, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERKs) that can phosphorylate various proteins. Inhibition of this pathway by PD98059 can lead to reduced phosphorylation and subsequent inhibition of proteins, potentially including zinc finger protein 948. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase, which might be involved in the stress response that could phosphorylate zinc finger proteins. Inhibiting p38 MAP kinase with SB203580 can therefore inhibit the functional activation of zinc finger protein 948. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which may phosphorylate substrates that can interact with zinc finger proteins. By inhibiting JNK, SP600125 can inhibit the phosphorylation of such substrates, potentially leading to the inhibition of zinc finger protein 948. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K is involved in multiple signaling pathways that regulate protein function. Inhibition of PI3K by LY294002 can lead to decreased activation of downstream targets, which may include proteins like zinc finger protein 948, resulting in its inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, it inhibits PI3K, leading to decreased activation of downstream proteins. This inhibition can extend to proteins such as zinc finger protein 948, inhibiting its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, which are upstream of ERK1/2 in the MAPK pathway. By inhibiting MEK, U0126 prevents the activation of ERK and subsequent phosphorylation of proteins, which could include zinc finger protein 948, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a central regulator of cell growth and metabolism. Inhibition of mTOR by rapamycin can lead to reduced protein synthesis and can indirectly inhibit the function of proteins including zinc finger protein 948. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By broadly inhibiting protein kinases, staurosporine can reduce the phosphorylation of proteins including zinc finger protein 948, leading to its inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a potent and selective inhibitor of protein kinase C (PKC). It functions similarly to chelerythrine by inhibiting the phosphorylation of proteins that require PKC activity, which may include zinc finger protein 948, thus inhibiting its function. | ||||||