BAZ2A Activators
BAZ2A, a chromatin remodeling protein, is intricately involved in the regulation of gene expression through its impact on chromatin structure. Its activity is modulated by various chemical compounds that influence chromatin accessibility and composition. S-Adenosylmethionine plays a crucial role in this context; it acts as a methyl donor in histone methylation, a process pivotal to BAZ2A's function in chromatin remodeling. This enhancement of histone methylation indirectly augments BAZ2A's ability to modify chromatin structure. Additionally, histone deacetylase inhibitors such as Mocetinostat, Panobinostat, Vorinostat, Entinostat, and Trichostatin A increase chromatin accessibility by preventing the removal of acetyl groups from histone tails. This alteration in chromatin structure facilitates BAZ2A's functional activity in modifying chromatin and regulating gene expression. Similarly, Nicotinamide, by inhibiting sirtuin deacetylases, contributes to this process, further enhancing BAZ2A's role in chromatin remodeling.
The functional dynamics of BAZ2A are also influenced by compounds that modulate other aspects of histone modification. For instance, 5-Azacytidine, by inhibiting DNA methyltransferases, reduces DNA methylation levels, thereby altering chromatin structure and enhancing BAZ2A's access to chromatin. Anacardic Acid and Curcumin, by affecting histone acetyltransferase activity, also play a role in modulating the chromatin landscape, indirectly enhancing BAZ2A's chromatin remodeling capabilities. Furthermore, Disulfiram and Parthenolide, by influencing both histone acetylation and methylation, contribute to the fine-tuning of the chromatin structure. These changes in the epigenetic landscape are critical for BAZ2A's function in regulating gene expression through chromatin remodeling. Collectively, these compounds, through their targeted effects on chromatin structure and histone modifications, facilitate the enhancement of BAZ2A-mediated functions, highlighting the complex interplay between chromatin dynamics and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine acts as a methyl donor in numerous methylation reactions. In the context of BAZ2A, it can enhance the protein's chromatin remodeling function by providing methyl groups necessary for histone methylation, a key process in which BAZ2A is involved. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can indirectly enhance BAZ2A activity. By reducing overall DNA methylation, it allows BAZ2A to access and remodel chromatin more effectively, thus enhancing its functional activity. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor. By inhibiting histone deacetylation, it indirectly enhances BAZ2A's chromatin remodeling function, as BAZ2A is involved in the regulation of chromatin structure and gene expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat, another histone deacetylase inhibitor, similarly enhances BAZ2A function by modulating chromatin structure. This alteration in chromatin accessibility indirectly supports BAZ2A's role in chromatin remodeling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor that indirectly enhances BAZ2A's activity by increasing chromatin accessibility, thereby facilitating BAZ2A-mediated chromatin remodeling. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat, a selective HDAC inhibitor, indirectly enhances BAZ2A's chromatin remodeling activity by altering histone acetylation levels, thus affecting chromatin structure and function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, acts as an inhibitor of sirtuins, a class of deacetylases. This can indirectly affect BAZ2A function by altering the acetylation status of histones and thus the chromatin structure, enhancing BAZ2A's chromatin remodeling capabilities. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that enhances BAZ2A activity by increasing chromatin accessibility, thereby aiding BAZ2A in its role in chromatin remodeling and gene expression regulation. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic Acid is a histone acetyltransferase inhibitor. By affecting the acetylation status of histones, it can indirectly enhance the activity of BAZ2A in chromatin remodeling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to affect histone acetylation. By modulating this process, it can indirectly enhance BAZ2A's role in chromatin remodeling and gene expression. | ||||||