Date published: 2025-10-25

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Barhl1 Inhibitors

Barhl1 Inhibitors represent a class of chemical compounds designed to modulate the activity of the Barhl1 protein, which is a transcription factor involved in the regulation of gene expression during embryonic development, particularly in neural differentiation processes. These inhibitors are developed to specifically target the Barhl1 protein and interfere with its transcriptional activity. The objective of such inhibitors is to gain insights into the molecular mechanisms through which Barhl1 functions and to explore its roles in various developmental processes.

The development of Barhl1 inhibitors is rooted in the broader field of molecular biology and developmental biology, aiming to understand the intricate regulatory networks that govern neural development. These inhibitors are designed to selectively bind to Barhl1 and alter its interaction with DNA or other proteins, thereby affecting the expression of downstream target genes. Researchers utilize these inhibitors as tools for experimental purposes, dissecting the precise functions of Barhl1 in the context of embryogenesis and neural differentiation. By inhibiting Barhl1 activity, scientists can investigate the effects on neural cell fate determination and the molecular pathways influenced by this transcription factor, contributing to a deeper understanding of the complex processes that underlie embryonic development. It's important to note that Barhl1 inhibitors are primarily used as research reagents and are valuable for advancing our knowledge of gene regulation and neural development.

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Items 11 to 20 of 24 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$246.00
$490.00
$536.00
16
(1)

Selectively inhibits JAK1 and JAK2 kinases, useful in myeloproliferative disorders.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus, disrupting cellular homeostasis and down-regulating Barhl1 expression.

ABT-199

1257044-40-8sc-472284
sc-472284A
sc-472284B
sc-472284C
sc-472284D
1 mg
5 mg
10 mg
100 mg
3 g
$116.00
$330.00
$510.00
$816.00
$1632.00
10
(0)

Targets the anti-apoptotic protein Bcl-2 in chronic lymphocytic leukemia.

1-β-D-Arabinofuranosylcytosine

147-94-4sc-201628
sc-201628A
sc-201628B
sc-201628C
sc-201628D
1 g
5 g
25 g
100 g
250 g
$147.00
$258.00
$508.00
$717.00
$1432.00
1
(1)

1-β-D-Arabinofuranosylcytosine inhibits DNA polymerase, leading to DNA damage and activation of DNA damage response pathways, ultimately suppressing Barhl1 expression.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Inhibits various tyrosine kinases, including BCR-ABL and SRC, for leukemia.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Actinomycin D inhibits RNA polymerase, preventing transcription of mRNA and leading to reduced levels of Barhl1 transcripts.

Allopurinol

315-30-0sc-207272
25 g
$128.00
(0)

Allopurinol inhibits xanthine oxidase, reducing the production of reactive oxygen species (ROS) and downstream oxidative stress responses that suppress Barhl1 expression.

Palbociclib

571190-30-2sc-507366
50 mg
$315.00
(0)

Inhibits cyclin-dependent kinases (CDK4 and CDK6), used in combination for breast cancer therapy.

Sunitinib, Free Base

557795-19-4sc-396319
sc-396319A
500 mg
5 g
$150.00
$920.00
5
(0)

Targets multiple receptor tyrosine kinases (VEGFR, PDGFR, KIT) in cancer.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A inhibits histone deacetylases (HDACs), leading to histone hyperacetylation and alterations in chromatin structure that down-regulate Barhl1 expression.