BARD1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil may reduce the expression of BARD1 by interfering with RNA synthesis and inducing DNA damage, subsequently affecting the cell cycle and potentially downregulating BARD1 as a part of the cellular response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin can cause DNA crosslinking and damage, possibly leading to a disruption in the normal function and expression of DNA repair proteins including BARD1, as the cell attempts to manage and respond to the induced stress. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin stabilizes the DNA topoisomerase I-DNA covalent complex, leading to DNA breaks. This significant alteration in DNA structure could potentially affect the expression of BARD1 as the cell responds to DNA damage. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a decrease in DNA synthesis. This could potentially result in altered expression of DNA repair proteins, including BARD1, as the cell adjusts to these changes. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts the DNA repair machinery. This disruption could potentially lead to changes in the expression of DNA repair proteins, including BARD1, as the cell responds to the DNA damage. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and disrupts cell division. This disruption in the cell cycle could potentially affect the expression of BARD1 as the protein is involved in cell cycle checkpoint control. | ||||||
Gemcitabine | 103882-84-4 | sc-481710 | 1 g | $112.00 | 13 | |
Gemcitabine is incorporated into DNA, leading to chain termination. This interference with DNA replication could potentially result in altered expression of DNA repair proteins, including BARD1. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits the proteasome, leading to an accumulation of proteins and potential cellular stress. This stress could potentially alter the expression of DNA repair proteins, including BARD1. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib targets multiple kinases and could potentially alter signaling pathways that regulate the expression of DNA repair proteins, including BARD1, affecting its levels in the cell. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine is a DNA methyltransferase inhibitor, potentially leading to changes in gene expression patterns. This could affect the expression of genes involved in DNA repair, including BARD1. | ||||||