BAP29 Activators
Chemicals that are categorized as potential activators of BAP29 primarily operate through the induction of ER stress and modulation of the UPR. This category encompasses agents that disrupt protein glycosylation, calcium homeostasis, and folding capacity within the ER, leading to a compensatory upregulation of proteins involved in maintaining ER function, such as BAP29. The perturbation of ER homeostasis by chemicals like Tunicamycin, Thapsigargin, and Beta-lapachone triggers a cellular stress response designed to restore equilibrium. This response can involve the activation of signaling pathways that include the elevation of various ER-associated proteins, among which BAP29 may be included due to its role in protein trafficking.
Furthermore, compounds like Salubrinal and Guanabenz, which target the phosphorylation state of eIF2α, demonstrate how subtle chemical interventions in translational control mechanisms can have broader implications for ER stress management, potentially affecting BAP29 activity. The use of proteasome inhibitors like MG132 can indirectly lead to the accumulation of proteins within the ER, which may necessitate the increased function of BAP29 in the ERAD pathway. Conversely, the application of chemical chaperones like 4-Phenylbutyrate underscores an alternative approach by aiding in protein folding, thereby potentially modulating BAP29's role within the ER under less stressed conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Induces the disassembly of the Golgi complex, causing a block in protein trafficking that can increase ER stress and potentially enhance BAP29 activity in response to altered homeostasis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Inhibits N-linked glycosylation in the ER, leading to ER stress which could upregulate BAP29 as part of the unfolded protein response (UPR). | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Selectively inhibits the ER calcium ATPase, inducing ER stress and potentially upregulating BAP29 as a part of the UPR. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
Acts as a chemical chaperone that can reduce ER stress and may modulate BAP29 function by improving overall protein folding capacity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to increased levels of misfolded proteins in the ER, possibly affecting BAP29 activity by enhancing ER-associated degradation (ERAD) pathways. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $110.00 $450.00 | 8 | |
Induces ER stress by generating reactive oxygen species (ROS), which could influence BAP29 activity through the UPR. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Selectively inhibits dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α), potentially enhancing BAP29 expression during ER stress. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Attenuates ER stress through inhibition of eIF2α dephosphorylation and may indirectly affect BAP29 activity in the UPR. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
Inhibits the integrated stress response (ISR) and can modulate ER stress outcomes, potentially influencing BAP29 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Modulates glycogen synthase kinase-3 (GSK-3) activity; while not directly related to BAP29, the alteration in cellular signaling may impact ER stress responses and BAP29 activity. | ||||||