beta-Lapachone CAS: 4707-32-8
MF: C15H14O3
MW: 242.27
A selective DNA topoisomerase I inhibitor.

β-Lapachone (CAS 4707-32-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 125ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Sinonimo: 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Applicazione: A selective DNA topoisomerase I inhibitor
Numero CAS: 4707-32-8
Purezza: ≥98%
Peso molecolare: 242.27
Formula molecolare: C15H14O3
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
Invia una review per questo prodotto e ricevi 15 Cruz Credits

β-Lapachone, a novel Topo I (topoisomerase I) inhibitor, does not stabilize the cleavable complex indicating a novel mode of action, unlike camptothecin (sc-200871). Apoptosis has been demonstrated in HL-60 and human prostate cancer cells treated with β-Lapachone via a p53-independent mechanism and cell cycle arrest at G0/G1,2. β-Lapachone has been observed to accelerate wound healing by increasing cell proliferation in cells such as: keratinocytes, fibroblasts and endothelial while also increasing the migration of fibroblasts and endothelial cells. β-Lapachone has exhibited anti-inflammatory properties by suppressing the NF-κB activation by blocking IκBα degradation and downregulating the ERK, p38 mitogen-activated protein kinase and Akt pathway.


Referenze

1. Planchon, S M., et al., 1995. Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. Cancer research. 55(17): 3706-11. PMID: 7641180
2. Li, C J., et al., 1993. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. The Journal of biological chemistry. 268(30): 22463-8. PMID: 8226754
3. Choi, Byung Tae., et al., 2003. beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. Anti-cancer drugs. 14(10): 845-50. PMID: 14597880
4. Moon, Dong-Oh., et al., 2007. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. International immunopharmacology. 7(4): 506-14. PMID: 17321474
5. Kung, Hsiu-Ni., et al., 2008. In vitro and in vivo wound healing-promoting activities of beta-lapachone. American journal of physiology. Cell physiology. 295(4): C931-43. PMID: 18650264
6. Dong, Guang Zhi., et al., 2010. Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB. Experimental & molecular medicine. 42(5): 327-34. PMID: 20200474

Utilizzo :
Store, as supplied, at room temperature for up to 1 year. Store solutions at - 20°C for up to 3 months.
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (>25 mg/ml), ethanol (20 mg/ml), chloroform, and DMF.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
~151-153° C (dec.)
Punto di ebollizione :
~381.4° C at 760 mmHg (Predicted)
Densità :
1.25 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.60
Attività ottica :
α20/D -43.9°, c = 2 in water
IC50 :
HIV-1 LTR: IC50 = 0.3 µM (human); HOS: IC50 = 1400 nM (human); MDA-MB-435 : IC50 = 0.06 ug.mL-1 (human); HL-60: IC50 = 1650 nM (human)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
QL6127400
PubChem CID :
3885
Numero MDL :
MFCD01712233
Registro Beilstein :
0181499
SMILES :
CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

beta-Lapachone  Citazioni prodotti

Vedi quanti altri hanno usato beta-Lapachone. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a6 di 6 totali

PMID: # 17609380  Bey, EA. et al. 2007. Proc. Natl. Acad. Sci. USA. 104: 11832-11837.

PMID: # 15044484  Lin, MT et al. 2004. J Biol Chem. 279: 24015-23.

PMID: # 12598645  Li, Y. et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 2674-2678.

PMID: # 9927052  Shiah, SG. et al. 1999. Cancer Res. 59: 391-398.

PMID: # 9927052  Shiah, SG. et al. 1999. Cancer Res. 59: 391-398.

PMID: # 2740334  Boothman, DA. et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 4963-4967.

Ciatazioni 1 a6 di 6 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 124ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 24ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

La Santa Cruz Biotechnology, Inc. è un leader mondiale nello sviluppo di prodotti per il mercato della ricerca biomedica. Chiamaci al numero gratuito 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. Tutti i diritti riservati. "Santa Cruz Biotechnology", ed il logo Santa Cruz Biotechnology, Inc."Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", il logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", ed "EZ Touch" sono marchi registrati dalla Santa Cruz Biotechnology, Inc.
Tutti i marchi sono proprietà dei rispettivi proprietari.