BANK1 Inhibitors
BANK1 inhibitors are a class of chemical compounds that have garnered interest in the fields of molecular biology and pharmacology due to modulating specific cellular processes. BANK1, or B-cell scaffold protein with ankyrin repeats 1, is a protein predominantly found in B lymphocytes, a crucial component of the immune system. This protein plays a pivotal role in the regulation of B-cell receptor (BCR) signaling and is involved in orchestrating various intracellular signaling pathways that influence B-cell activation, proliferation, and antibody production. BANK1 inhibitors are designed to interact with the active site or binding domain of the BANK1 protein, effectively inhibiting its function and influencing cellular processes dependent on BANK1-mediated BCR signaling.
Structurally, BANK1 inhibitors are engineered to selectively target the active site or binding domains of BANK1, ensuring high specificity for this particular scaffolding protein. By inhibiting BANK1, these compounds may disrupt its role in BCR signaling, leading to alterations in B-cell activation and antibody production. The study of BANK1 inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions in the immune system, particularly in the context of B-cell responses. This knowledge contributes to our understanding of basic immunology and may have implications in various research areas, including autoimmune diseases, antibody-mediated disorders, and the molecular basis of immune dysregulation. However, further research is required to fully explore the extent of their applications and their impact on cellular physiology in the context of BANK1-mediated BCR signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation, which could nonspecifically reduce overall protein levels, including the synthesis of BANK1. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA synthesis, which can decrease mRNA levels for various genes and potentially reduce BANK1 protein expression as a consequence of reduced transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to inhibit the transcription of multiple genes by affecting RNA polymerase II activity. This could lead to reduced BANK1 mRNA and protein levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine interferes with lysosomal acidification and could indirectly affect the degradation pathways of various cellular components, which may alter the expression levels of proteins including BANK1. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts lysosomal function and could affect intracellular trafficking, with potential downstream effects on the expression of certain proteins like BANK1. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, which could result in reduced proliferation of B-cells and potentially lower expression of B-cell-specific proteins including BANK1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that can incorporate into RNA and DNA and affect methylation patterns, possibly leading to alterations in gene expression including that of BANK1. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin causes premature chain termination during protein synthesis, which could nonspecifically decrease the production of many proteins, potentially including BANK1. | ||||||
Roxithromycin | 80214-83-1 | sc-205845 sc-205845A | 1 g 5 g | $52.00 $156.00 | ||
Roxithromycin is known to bind to the 50S subunit of the bacterial ribosome, and while its effects on eukaryotic cells are less clear, it could potentially influence protein synthesis and expression, including that of BANK1. | ||||||
Nitazoxanide | 55981-09-4 | sc-212397 | 10 mg | $124.00 | 1 | |
Nitazoxanide interferes with pyruvate-ferredoxin oxidoreductase, which may potentially affect various cellular processes and indirectly influence the expression levels of proteins like BANK1. | ||||||