Bag-3 Inhibitors
Bag-3 inhibitors comprise a diverse group of chemical compounds that exert their influence on the Bag-3 protein through various mechanisms. Geldanamycin and its derivative, 17-AAG, act as direct Hsp90 inhibitors, disrupting the chaperone machinery crucial for Bag-3 stability. Celastrol, another Hsp90-Cdc37 complex inhibitor, contributes to Bag-3 modulation by affecting the protein folding environment. VER-155008 and Quercetin, targeting Hsp70, indirectly impact Bag-3, as it interacts with Hsp70 in cellular processes. Inhibition of HSF1 by KRIBB11 alters the cellular stress response, indirectly affecting Bag-3, a participant in stress-related pathways. The metabolic modulator 2-Deoxyglucose influences Bag-3 by disrupting glycolysis and perturbing energy-dependent processes. Bortezomib, a proteasome inhibitor, indirectly impacts Bag-3 turnover by interfering with protein degradation pathways.
SB203580 and SB216763, inhibitors of p38 MAPK and GSK-3, respectively, modulate signaling pathways connected to Bag-3. SB431542, targeting the TGF-β type I receptor, indirectly influences Bag-3 by disrupting TGF-β signaling, to which Bag-3 is intricately linked. PF-3758309, an Akt inhibitor, alters the PI3K-Akt signaling pathway, indirectly affecting Bag-3 regulatory dynamics. These diverse Bag-3 inhibitors, through their specific interactions with cellular pathways and molecular targets, collectively contribute to the modulation of Bag-3, providing valuable tools for understanding and manipulating cellular processes involving this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin, a benzoquinone ansamycin antibiotic, functions as an Hsp90 inhibitor. By binding to Hsp90, it disrupts the chaperone function, leading to the degradation of client proteins, including Bag-3, involved in cellular processes and signaling pathways. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG, a derivative of geldanamycin, inhibits Hsp90 and consequently modulates Bag-3. This compound disrupts the chaperone activity of Hsp90, affecting the stability and function of Bag-3 within cellular processes. | ||||||
VER 155008 | 1134156-31-2 | sc-358808 sc-358808A | 10 mg 50 mg | $199.00 $825.00 | 9 | |
VER-155008 is a selective Hsp70 inhibitor. By targeting Hsp70, it indirectly influences Bag-3, which interacts with Hsp70. The inhibition of Hsp70 disrupts the protein folding machinery, impacting Bag-3 stability and function. | ||||||
KRIBB11 | 342639-96-7 | sc-507391 | 5 mg | $95.00 | ||
KRIBB11, an inhibitor of heat shock factor 1 (HSF1), indirectly affects Bag-3 by disrupting the cellular stress response. Bag-3 is part of the stress response network, and inhibition of HSF1 alters its expression and function. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol, a triterpenoid, inhibits the Hsp90-Cdc37 chaperone complex, leading to the degradation of client proteins, including Bag-3. This disruption impacts the stability and activity of Bag-3 within cellular pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, acts as an Hsp70 inhibitor. By targeting Hsp70, it indirectly modulates Bag-3, which interacts with Hsp70. The disruption of Hsp70 function influences Bag-3 stability and its role in cellular processes. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxyglucose, an analog of glucose, inhibits glycolysis and influences the cellular energy status. This metabolic modulation indirectly impacts Bag-3, as its function is interconnected with energy-dependent cellular processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, disrupts protein degradation pathways. By affecting the ubiquitin-proteasome system, it indirectly influences Bag-3 turnover, altering its abundance and function within cellular processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, modulates the MAPK signaling pathway. Bag-3 interacts with components of this pathway, and inhibiting p38 MAPK indirectly affects Bag-3 function by altering its regulatory interactions. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763, a GSK-3 inhibitor, influences the Wnt signaling pathway. As Bag-3 is implicated in Wnt pathway modulation, inhibiting GSK-3 indirectly impacts Bag-3 function by altering the regulatory dynamics of the Wnt pathway. | ||||||