ATP1AL1 inhibitors, also known as ATPase, Na+/K+ transporting, alpha-like 1 inhibitors, are a class of chemical compounds designed to target and modulate the activity of the ATP1AL1 enzyme. ATP1AL1, or Sodium-Potassium-ATPase alpha-like 1, is a member of the P-type ATPase family of ion transporters found in various tissues and cell types within the human body. This enzyme plays a critical role in the active transport of sodium and potassium ions across cellular membranes, which is essential for maintaining the electrochemical gradients necessary for numerous physiological processes. ATP1AL1 is particularly abundant in the central nervous system and is implicated in neuronal excitability and neurotransmission.
ATP1AL1 inhibitors work by interfering with the function of the ATP1AL1 enzyme, disrupting its ability to pump sodium and potassium ions across the cell membrane. This disruption can have profound effects on cellular physiology, leading to alterations in membrane potential and ion concentrations within cells. These inhibitors typically bind to specific sites on the ATP1AL1 enzyme, inhibiting its activity and thereby affecting the ionic balance within cells. This class of compounds is of great interest to researchers studying the molecular mechanisms underlying neural signaling, as well as those investigating applications in various cellular processes that rely on ion transport. Understanding the precise mechanisms by which ATP1AL1 inhibitors function can provide valuable insights into cellular physiology and lead to the development of novel strategies in the future.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain inhibits the Na+/K+ ATPase pump by binding to its α-subunit, impairing ion transport. This leads to an increase in intracellular sodium and calcium levels, affecting various cellular processes | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin, a cardiac glycoside, inhibits Na+/K+ ATPase, increasing intracellular sodium and calcium concentrations, thereby enhancing cardiac contractility. | ||||||
Digitoxin | 71-63-6 | sc-207577 sc-207577A sc-207577B sc-207577C sc-207577D | 250 mg 500 mg 1 g 5 g 10 g | $110.00 $182.00 $313.00 $1080.00 $2000.00 | 2 | |
Digitoxin inhibits Na+/K+ ATPase activity, increasing intracellular sodium and calcium, which in turn strengthens cardiac muscle contractions. | ||||||
Bufalin | 465-21-4 | sc-200136 sc-200136A sc-200136B sc-200136C | 10 mg 25 mg 50 mg 100 mg | $97.00 $200.00 $334.00 $533.00 | 5 | |
Bufalin inhibits Na+/K+ ATPase activity, disrupting ion gradients, and affecting cellular processes, including cardiac contractility. | ||||||
Strophanthidin | 66-28-4 | sc-215914 sc-215914A | 250 mg 1 g | $211.00 $678.00 | 2 | |
Strophanthidin inhibits the Na+/K+ ATPase pump, disrupting ion balance within cells, which influences cardiac muscle contraction and other cellular functions. | ||||||