Atlastin-2 Activators
Atlastin-2 activators are compounds that enhance the functional activity of Atlastin-2 through various biochemical and cellular mechanisms. GTP and its non-hydrolyzable analog GTPγS are directly involved in the GTPase cycle of Atlastin-2, providing the necessary energy for conformational changes that drive membrane fusion. Farnesyltransferase and geranylgeranyltransferase inhibitors play a role in proper localization of Atlastin-2 to the ER membrane by preventing the addition of lipid modifications that could mislocalize Atlastin-2, thus ensuring its functionality in ER network formation. Lipid-modifying compounds such as sphingosine and phosphatidylinositol 4-phosphate alter the lipid environment of the ER membrane, which can facilitate Atlastin-2's activity. Bisphenol A and ethanol, by affecting membrane fluidity, create favorable conditions for Atlastin-2-mediated membrane fusion.
The reduction of disulfide bonds within Atlastin-2 by agents like Dithiothreitol enhances its GTPase activity, which is essential for ER fusion events. MLN64 START domain inhibitors and Sar1p activators indirectly enhance Atlastin-2's role in membrane dynamics by maintaining a sterol-rich environment and initiating COPII vesicle formation, respectively. These latter processes ensure that the cellular context is primedfor the increased demands on ER fusion, necessitating greater Atlastin-2 activity. Lastly, calcium ionophores, by elevating intracellular calcium levels, can indirectly enhance Atlastin-2 function by activating calcium-dependent processes that influence ER morphology and dynamics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine-5′-Triphosphate, Disodium salt | 86-01-1 | sc-507564 | 1 g | $714.00 | ||
GTP binds directly to Atlastin-2 and provides the energy required for the GTPase activity that is central to Atlastin-2's function in membrane fusion and ER network formation. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine is a bioactive lipid that can enhance the activity of Atlastin-2 by influencing the lipid composition of the endoplasmic reticulum (ER), thus modulating its membrane curvature and facilitating membrane fusion events. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS, a non-hydrolyzable analog of GTP, can bind to Atlastin-2 and stabilize its active conformation, thus potentially enhancing its GTPase activity and promoting ER fusion. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can alter the physical properties of cellular membranes. This alteration could enhance the membrane fusion activity of Atlastin-2 by making the lipid bilayer more conducive to the fusion process. | ||||||