ATAD2B Inhibitors

ATAD2B inhibitors encompass a range of compounds that are predicted to modulate the function of ATAD2B, a protein that may be involved in chromatin remodeling and gene transcription regulation. The chemical inhibitors listed above are primarily targeting the bromodomains of the BET protein family. Since ATAD2B is closely related to ATAD2, which contains a bromodomain, these inhibitors are anticipated to bind to any similar domain within ATAD2B, preventing the protein from interacting with acetylated lysines on histones, thereby potentially inhibiting its role in transcriptional activation. The binding of these inhibitors to the bromodomain pocket is presumed to be competitive, occupying the site where the acetylated lysines would normally bind and thus preventing the subsequent steps required for gene expression modulation.

The functional impact of these inhibitors on ATAD2B is premised on the disruption of protein-protein interactions and the alteration of gene expression patterns. If ATAD2B possesses ATPase activity, as its paralog ATAD2 does, compounds that can inhibit ATPases might also be effective in modulating its activity. This would involve the obstruction of the energy-dependent processes that ATAD2B may facilitate. Additionally, some compounds like Nitazoxanide, which have broad biological activity, are included in consideration of their potential to perturb cellular pathways that could indirectly affect ATAD2B function.