ASH2L Inhibitors

The chemical class of ASH2L inhibitors primarily includes compounds that influence epigenetic modification processes, such as histone methylation and acetylation. These inhibitors indirectly affect ASH2L's function by targeting the enzymes responsible for modifying chromatin, thereby influencing the transcriptional regulation in which ASH2L is involved.

Compounds like 5-Azacytidine and histone deacetylase inhibitors (e.g., Trichostatin A, Vorinostat, SAHA, Mocetinostat, Entinostat, Panobinostat, Romidepsin) alter the epigenetic landscape, which is integral to the processes regulated by ASH2L. These inhibitors can modify the accessibility of chromatin, potentially affecting the sites where ASH2L acts in conjunction with the SET1/MLL complex. By altering histone acetylation and methylation states, these compounds can indirectly modulate ASH2L's role in gene expression regulation. In addition, inhibitors of BET bromodomains like JQ1 and I-BET151, and EZH2 inhibitors like GSK343, can also indirectly affect ASH2L's function. These compounds modulate the binding of proteins to specific histone modifications, thereby influencing the transcriptional regulation activities in which ASH2L participates.