ASB-14 Inhibitors
ASB-14 inhibitors are chemical compounds that target and modulate the activity of ASB-14, a member of the ankyrin repeat and SOCS box-containing protein family. This protein family is known for its role in various cellular processes, particularly in ubiquitin-mediated protein degradation. ASB-14 specifically is associated with the regulation of the ubiquitination pathway, where it functions by interacting with cullin-RING ligases, influencing the degradation of specific protein substrates within the cell. By inhibiting ASB-14, these compounds can potentially modulate the stability and turnover of proteins that are essential to maintaining cellular homeostasis.
ASB-14 inhibitors can vary in structure, often designed to fit within the binding site of ASB-14, thereby preventing its normal interaction with its molecular partners. They may possess distinct functional groups that enable them to interact with specific amino acid residues on the ASB-14 protein, thereby altering its activity. Such inhibitors can be used as valuable tools in research to investigate the biological pathways influenced by ASB-14, including protein degradation, cell cycle control, and signal transduction. These compounds are also utilized to better understand the mechanistic role of ASB-14 in cellular functions and the broader ubiquitin-proteasome system. Their study provides insight into the fundamental molecular interactions that govern protein regulation within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can increase chromatin acetylation, leading to a more open chromatin structure which might, in some cases, result in the downregulation of ASB-14 due to altered transcription factor accessibility. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could decrease methylation levels on the ASB-14 gene, potentially leading to its downregulation by disrupting transcriptional activation processes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
By intercalating into DNA, Actinomycin D can inhibit RNA polymerase movement, potentially leading to a decrease in ASB-14 mRNA synthesis and subsequent protein expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
This proteasome inhibitor might increase the half-life of proteins that usually degrade transcription factors involved in ASB-14 transcription, thereby potentially reducing the expression of the ASB-14 gene. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
As an inhibitor of ribosomal translocation, Cycloheximide can halt protein synthesis globally, which would include a decrease in ASB-14 protein production. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
This mTOR inhibitor can lead to the deactivation of protein synthesis pathways, potentially resulting in decreased synthesis of the ASB-14 protein. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
By selectively binding to GC-rich DNA sequences, Mithramycin A can disrupt specific transcription factor-DNA interactions, potentially leading to decreased transcription of genes like ASB-14. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
By inhibiting RNA polymerase II, α-Amanitin can dramatically reduce the transcription of mRNA, including that of ASB-14, likely leading to a substantial decline in ASB-14 protein levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to intercalate into DNA, Chloroquine can inhibit nucleic acid synthesis which might lead to a reduction in the transcription and expression of ASB-14. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
This small molecule inhibits the interaction between bromodomain proteins and acetylated histones, potentially leading to the downregulation of ASB-14 expression due to changes in chromatin dynamics and transcriptional control. | ||||||