ARV1 Inhibitors
ARV1 inhibitors constitute a class of chemical compounds specifically designed to target and modulate the activity of the ARV1 protein. ARV1, also known as acyl-CoA:cholesterol acyltransferase-related domain-containing protein 1, is an integral membrane protein localized in the endoplasmic reticulum (ER) and Golgi apparatus. This protein plays a crucial role in lipid metabolism, specifically in the regulation of the intracellular distribution and trafficking of lipids and cholesterol. Inhibitors designed to target ARV1 are primarily employed in molecular and cellular biology research to gain insights into the functional properties and regulatory mechanisms associated with this protein's role in lipid homeostasis.
The development of ARV1 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with ARV1 and modulate its lipid-related activities. By inhibiting ARV1, these compounds disrupt its function in lipid and cholesterol trafficking, affecting the distribution and metabolism of lipids within the cell. Researchers use ARV1 inhibitors to investigate the intricate roles played by ARV1 in maintaining cellular lipid balance, exploring its contributions to lipid-related processes such as membrane formation, lipid storage, and cholesterol regulation. Furthermore, these inhibitors serve as valuable tools for dissecting the broader network of cellular pathways involving lipid metabolism and trafficking, contributing to our understanding of fundamental cell biology mechanisms and providing insights into avenues for further scientific exploration.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil is a pyrimidine analog that can interfere with DNA synthesis, potentially affecting gene expression and protein synthesis. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin binds to DNA and causes strand breaks, which can lead to altered gene expression and protein synthesis. | ||||||
Topotecan | 123948-87-8 | sc-338718 | 100 mg | $582.00 | ||
Topotecan inhibits topoisomerase I, affecting DNA replication and transcription, thus potentially influencing protein expression. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $29.00 $81.00 $260.00 $791.00 $1977.00 | ||
Vinorelbine interferes with microtubule assembly, affecting cell division and potentially gene expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90 and interferes with its function, potentially affecting the stability and function of several client proteins. | ||||||
(+)-Irinotecan | 97682-44-5 | sc-269253 | 10 mg | $62.00 | 1 | |
Irinotecan inhibits topoisomerase I, like topotecan, and can influence DNA replication and transcription. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $420.00 | 32 | |
Lapatinib is a dual inhibitor of EGFR and HER2 tyrosine kinases, affecting signaling pathways involved in gene expression. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
Everolimus is an mTOR inhibitor, like sirolimus, and can affect protein synthesis and cell growth. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Nilotinib is a tyrosine kinase inhibitor, affecting signaling pathways that can influence gene expression. | ||||||