Arrestin-C Activators

The class of Arrestin-C activators comprises a variety of chemical compounds that can indirectly influence the activity of Arrestin-C (ARR3) through their effects on GPCR signaling pathways and related cellular processes. This group includes molecules such as Forskolin and Caffeine, which can modulate cAMP levels, potentially affecting GPCR signaling and thereby influencing ARR3 activity. These compounds can impact the regulatory mechanisms of GPCRs, with which ARR3 interacts.

Other compounds in this class, like Retinoic Acid and Vitamin A, are crucial for phototransduction pathways, especially in retinal cells where ARR3 plays a significant role. The modulation of these pathways could potentially influence ARR3 activity in the context of vision. Curcumin, Resveratrol, and Epigallocatechin Gallate (EGCG), known for their effects on various cellular signaling pathways, including those related to aging and metabolism, might also modulate ARR3 activity. Antioxidants like Quercetin, are integral to this class for their potential roles in modulating GPCR dynamics and cellular signaling environments. Sulforaphane and Zinc, affecting gene expression and cellular signaling, could also have an indirect effect on ARR3 activity.