Arrestin-C Antibody (2D7): sc-293296

Arrestin-C Antibody (2D7) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Arrestin-C protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Arrestin-C antibody (2D7) is available as a non-conjugated antibody, specifically designed to facilitate research into the complex roles of Arrestin-C in cellular signaling. Arrestin-C, also known as retinal cone arrestin-3, X-arrestin, or cArr, is primarily located in the retina and pineal gland, where Arrestin-C localizes to the inner and outer segments of red, green, and blue cone photoreceptors, as well as the inner plexiform regions. This strategic localization is crucial for Arrestin-C function in retina-specific signal transduction, as Arrestin-C binds to photoactivated-phosphorylated opsins, thereby playing a vital role in the visual phototransduction cascade. Arrestin-C exists in two isoforms due to alternative splicing, with isoform 1 being the full-length mature protein and isoform 2 being truncated at amino acid residue 359. Notably, Arrestin-C expression is stimulated by retinoic acid, highlighting Arrestin-C importance in retinal development and function. Furthermore, Arrestin-C can form homodimers and oligomers with β-Arrestins, suggesting a regulatory role in β-Arrestin-mediated signaling pathways, which are essential for modulating cellular responses to various stimuli.

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Arrestin-C Antibody (2D7) References:

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