ARMC2 Inhibitors
Chemical inhibitors of ARMC2 exert their modulatory effects primarily through interactions with microtubule dynamics, essential for the structural and functional integrity of cellular components such as cilia and flagella. Colchicine, for instance, binds to tubulin and disrupts microtubule polymerization, which is a fundamental process for cell division and intracellular transport. This disruption can impair ARMC2's function in flagella structure and sperm motility. Similarly, Vinblastine targets microtubule assembly, crucial for cellular transport and structure, thereby inhibiting ARMC2's role in the maintenance of cilia and flagella. Nocodazole, with its ability to disrupt microtubule polymerization, and Podophyllotoxin, which inhibits tubulin polymerization, also negatively affect ARMC2's associated functions within microtubule organizing centers (MTOCs), which are critical for proper flagellar and cilia function.
Other chemicals, such as Paclitaxel, stabilize microtubules and prevent their disassembly, which can impair ARMC2 function by disrupting the dynamic balance required for normal flagellar function. Eribulin inhibits microtubule growth without affecting their shortening, potentially freezing the dynamic processes essential for ARMC2's role in microtubule-based transport and structural maintenance. Griseofulvin and Destruxin B, which impair microtubule function by binding to tubulin and depolymerizing microtubules respectively, can inhibit processes vital for sperm development and flagella structural integrity, where ARMC2 is implicated. Moreover, Combretastatin A4 and Albendazole, both of which target tubulin and interfere with microtubule polymerization, can affect ARMC2's role in the formation and function of flagella and cilia. Finally, Noscapine and Thiabendazole disrupt ARMC2's functionality by altering microtubule dynamics and inhibiting enzymes related to microtubule assembly, which is indispensable for the assembly and maintenance of proper ciliary and flagellar structures.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule polymerization, which is critical for cell division and intracellular transport mechanisms. As ARMC2 is implicated in sperm motility and flagella structure, which rely on proper microtubule formation, colchicine can inhibit ARMC2 function by destabilizing the microtubules it depends on. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can impede the normal function of ARMC2 in sperm motility by disrupting the dynamics necessary for flagellar and ciliary functions where ARMC2 is involved. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule assembly, which is essential for cellular transport and structure. Inhibiting microtubule assembly can inhibit ARMC2's role in the structural integrity of cilia and flagella and therefore its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. By altering microtubule dynamics, nocodazole can inhibit ARMC2's role in processes such as sperm flagella function that are dependent on microtubule structures. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds tubulin and inhibits its polymerization. This action can inhibit ARMC2's associated function within the microtubule organizing centers (MTOCs), which are critical for proper flagella and cilia function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, impairing the mitotic spindle formation. This can inhibit ARMC2's role in cellular processes that rely on the mitotic spindle and microtubule integrity, such as sperm development. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, thus freezing microtubule dynamics. This can inhibit ARMC2 function by preventing necessary microtubule-based transport and structural processes. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole interferes with microtubule polymerization. This action can inhibit ARMC2's associated functions, particularly in the formation and function of flagella and cilia, which are dependent on intact microtubules. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine binds to tubulin and alters microtubule dynamics, which can inhibit ARMC2's role in microtubule-dependent mechanisms within flagella and ciliary functions. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits fumarate reductase, an enzyme related to microtubule assembly. This inhibition can affect ARMC2 function by disrupting the energy metabolism needed for the assembly and maintenance of ciliary and flagellar structures. | ||||||