ARL15 Activators

ARL15 activators are a selection of chemical compounds that could potentially enhance the functional activity of ARL15, a GTP-binding protein involved in vesicle transport, lipid metabolism, and signal transduction. Compounds like GTPγS are crucial as they can stabilize ARL15 in its active, GTP-bound state, thereby potentially enhancing its GTPase activity. Farnesyltransferase inhibitors like Tipifarnib and geranylgeranyltransferase inhibitors like GGTI-298 target post-translational modifications that are essential for the proper functioning and localization of proteins like ARL15, thereby potentially influencing its role in cellular signaling and vesicle transport.

Statins, including Atorvastatin, Lovastatin, and Simvastatin, along with other lipid-lowering agents like Clofibrate and Niacin, are included due to their roles in modulating lipid metabolism pathways. These compounds could potentially enhance the role of ARL15 in regulating lipid metabolic processes. Brefeldin A and Phenylarsine Oxide, known for their effects on disrupting vesicular trafficking and Golgi function, offer insights into how alterations in these cellular processes might influence ARL15's activity. Nitrendipine, a calcium channel blocker, and Dynasore, a dynamin inhibitor, represent a broader approach by targeting calcium-dependent signaling and vesicular trafficking, respectively.