ARK Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib binds to Aurora A kinase in its ATP-binding pocket, preventing kinase activation and leading to cell cycle arrest and apoptosis. | ||||||
OM137 | 292170-13-9 | sc-255403 | 5 mg | $67.00 | ||
OM137, as an acid halide, exhibits remarkable reactivity through its electrophilic carbonyl group, which readily engages in nucleophilic acyl substitution reactions. This compound's unique halogen substituent enhances its reactivity profile, facilitating rapid interactions with various nucleophiles. The steric effects of its substituents can influence reaction kinetics, leading to distinct pathways in synthetic applications. Additionally, OM137's ability to form transient intermediates contributes to its versatility in organic transformations. | ||||||
AZD1152-HQPA | 722544-51-6 | sc-265334 | 10 mg | $375.00 | ||
Barasertib, as AZD1152-HQPA, inhibits Aurora B kinase, disrupting chromosome alignment, spindle checkpoint function, and cytokinesis. | ||||||
KW 2449 | 1000669-72-6 | sc-364518 sc-364518A | 10 mg 50 mg | $180.00 $744.00 | ||
KW 2449, as an acid halide, showcases exceptional reactivity due to its highly electrophilic carbonyl moiety, which readily participates in nucleophilic attacks. The presence of a halogen atom significantly amplifies its reactivity, allowing for swift interactions with a range of nucleophiles. Its unique steric configuration can modulate reaction rates and pathways, while the formation of reactive intermediates enhances its utility in diverse synthetic processes. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $61.00 $85.00 | 4 | |
Tozasertib binds to Aurora A and B kinases, inhibiting their activities and causing defects in spindle assembly and chromosome segregation. | ||||||
7-Aminoindole | 5192-04-1 | sc-257005 | 1 g | $555.00 | ||
7-Aminoindole, as an acid halide, exhibits remarkable electrophilic characteristics, primarily driven by its carbonyl group, which is highly susceptible to nucleophilic attack. The presence of the amino group introduces intriguing steric and electronic effects, influencing reaction dynamics and selectivity. Its ability to form stable intermediates facilitates complex reaction pathways, making it a versatile participant in various chemical transformations and synthetic strategies. | ||||||