Molecular structure of OM137, CAS Number: 292170-13-9
OM137 (CAS 292170-13-9)
Alternate Names:
2-Amino-N′-(4-hydroxy-3-methoxybenzylidene)-4-methyl-1,3-thiazole-5-carbohydrazide
Application:
OM137 is an ARK inhibitor
CAS Number:
292170-13-9
Purity:
≥95%
Molecular Weight:
306.34
Molecular Formula:
C13H14N4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
OM137 is an inhibitor of ARKs. It is an aminothiazole derivative, which functions to override the spindle checkpoint primarily through inhibition of the ARKs (mitotic kinases). OM137 is a more potent inhibitor of ARK-2 compared with ARK-1 in vitro. The compounda has some CDK1 inhibitory activity, but is likely that the major mode by which it drives mitotic exit of cells arrested in M phase via the spindle checkpoint is through its inhibitory activity against ARK-2.
OM137 (CAS 292170-13-9) References
- A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. | DeMoe, JH., et al. 2009. Cancer Res. 69: 1509-16. PMID: 19190331
- Gene Expression Analysis to Assess the Relevance of Rodent Models to Human Lung Injury. | Sweeney, TE., et al. 2017. Am J Respir Cell Mol Biol. 57: 184-192. PMID: 28324666
Inhibitor of:
ARK, and ARK-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OM137, 5 mg | sc-255403 | 5 mg | $68.00 |