Date published: 2026-5-3

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ARFGAP1 Inhibitors

Santa Cruz Biotechnology now offers a broad range of ARFGAP1 Inhibitors for use in various applications. ARFGAP1 inhibitors are a significant category of chemicals used in scientific research to study the regulation of the ADP-ribosylation factor (ARF) GTPase activity, particularly in the context of vesicle trafficking and membrane dynamics. ARFGAP1 is a GTPase-activating protein that facilitates the hydrolysis of GTP bound to ARF proteins, thereby controlling the cycle of ARF activation and inactivation, which is crucial for the formation of vesicles in the Golgi apparatus and other membrane-bound compartments. By inhibiting ARFGAP1, researchers can investigate the effects of prolonged ARF activity on cellular processes, such as the formation of transport vesicles, the organization of the Golgi structure, and the dynamics of membrane trafficking. These inhibitors are invaluable tools for dissecting the role of ARFGAP1 in maintaining cellular homeostasis and for understanding how disruptions in ARF signaling pathways contribute to cellular dysfunction. Furthermore, ARFGAP1 inhibitors are employed in studies focused on the interplay between ARF proteins and other regulatory molecules involved in lipid metabolism, cytoskeleton organization, and signal transduction. Their use in experimental settings allows scientists to explore the precise mechanisms by which ARFGAP1 modulates the spatial and temporal aspects of vesicle formation and transport within cells. The availability of a wide range of ARFGAP1 inhibitors enables researchers to tailor their investigations to specific aspects of membrane trafficking and to advance our understanding of the molecular machinery that governs intracellular transport. View detailed information on our available ARFGAP1 Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wnt Synergist, QS11

944328-88-5sc-222417
sc-222417A
5 mg
25 mg
$141.00
$607.00
(1)

Wnt Synergist, QS11, functions as an arfgap1 by modulating the GTPase activity of ARF proteins, thereby influencing intracellular signaling pathways. Its unique molecular structure facilitates specific interactions with ARF-GAP complexes, enhancing the hydrolysis of GTP to GDP. This action alters the dynamics of membrane trafficking and cytoskeletal organization, contributing to the regulation of cellular morphology and function. The compound's distinct binding affinity underscores its role in cellular communication and organization.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Brefeldin A inhibits ARFGAP by disrupting COPI-mediated vesicular trafficking, leading to Golgi complex disassembly and ER-to-Golgi transport inhibition.

Itraconazole

84625-61-6sc-205724
sc-205724A
50 mg
100 mg
$78.00
$142.00
23
(1)

Itraconazole inhibits ARFGAP by disrupting ARF1 activation, leading to impaired Golgi function and vesicular trafficking.