APOBEC3B Inhibitors
CENP-B inhibitors are a class of chemical compounds that target a specific protein known as Centromere Protein B (CENP-B). CENP-B is a crucial component of the centromere, a specialized region on chromosomes that plays a pivotal role in cell division and chromosome segregation. The centromere ensures that genetic material is distributed accurately to daughter cells during cell division. CENP-B itself is essential for maintaining the structural integrity and function of the centromere. Its primary role is to bind to a specific DNA sequence within the centromere known as the CENP-B box, which helps organize and stabilize the kinetochore, a protein complex that attaches to spindle fibers and facilitates chromosome movement during mitosis and meiosis.
CENP-B inhibitors are designed to interfere with the interaction between CENP-B and the CENP-B box DNA sequence. By disrupting this binding, these inhibitors disrupt the proper assembly and function of the centromere and kinetochore, leading to errors in chromosome segregation during cell division. This disruption can have significant consequences for cell viability and genomic stability. Researchers have been exploring CENP-B inhibitors as valuable tools in understanding the fundamental processes of cell division and chromosome segregation, shedding light on the intricate molecular mechanisms involved. Additionally, these inhibitors have the ability to be used in various research contexts, such as in studies investigating the regulation of centromere function and the development of novel approaches for manipulating chromosome behavior in a controlled manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known for its anti-inflammatory properties. It may inhibit APOBEC3B by interfering with NF-kB signaling, a pathway that can control the expression of this enzyme. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, may downregulate APOBEC3B expression through its antioxidant properties and by modulating signaling pathways involved in cellular stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a polyphenolic compound, resveratrol may reduce APOBEC3B levels by modulating the SIRT1 pathway, which is implicated in cellular stress and aging processes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Found in cruciferous vegetables, sulforaphane may decrease APOBEC3B expression by activating NRF2, a transcription factor involved in the cellular defense mechanism. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
This compound, found in cruciferous vegetables, can modulate estrogen metabolism and might influence APOBEC3B expression through hormonal regulation pathways. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Traditionally used in the management of alcohol dependence, disulfiram can inhibit proteasome activity, which could lead to reduced APOBEC3B levels indirectly through altered protein degradation mechanisms. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, found in berries and pomegranates, may exhibit its inhibitory effect on APOBEC3B by counteracting oxidative stress and modulating related signaling pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
This flavonoid may downregulate APOBEC3B expression by impacting pathways related to inflammation and carcinogenesis, such as the WNT/β-catenin pathway. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin, a flavonoid found in honey and propolis, may reduce APOBEC3B levels through its anti-inflammatory properties and by influencing estrogen receptor signaling. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Present in apple peels, ursolic acid might suppress APOBEC3B by modulating the MAPK pathway, which is involved in the regulation of gene expression and cell survival. | ||||||