APLF Inhibitors
APLF inhibitors belong to a distinct chemical class of compounds that have garnered significant attention due to their unique mechanism of action and implications in various biological processes. These inhibitors are characterized by their ability to target and modulate the activity of APLF, a crucial protein involved in DNA repair and maintenance pathways. APLF, which stands for Aprataxin PNK-like factor, plays an essential role in repairing DNA damage, particularly in instances of double-strand breaks and interstrand crosslinks. The inhibitors designed to interact with APLF typically act by interfering with its binding affinity to specific DNA structures, impeding its function in orchestrating repair processes.
By doing so, APLF inhibitors have shown the influence DNA repair mechanisms, and their study has provided insights into the complex interplay of cellular pathways that maintain genomic stability. The development and exploration of APLF inhibitors represent a significant stride in understanding the intricate molecular processes that govern DNA repair, with applications extending to various fields including molecular biology, genetics, and cell biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DNA-PK Inhibitor II | 154447-35-5 | sc-202143 sc-202143A | 10 mg 50 mg | $155.00 $660.00 | 6 | |
NU7026 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in DNA repair. It competes with ATP, blocking the kinase activity of DNA-PK, thus interfering with the repair of double-strand breaks in DNA. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
KU55933 is a selective inhibitor of ataxia-telangiectasia mutated (ATM) kinase. By inhibiting ATM, it disrupts the DNA damage response pathway, leading to impaired DNA repair and cell cycle arrest in response to DNA double-strand breaks. | ||||||
ETP-46464 | 1345675-02-6 | sc-497432 | 10 mg | $550.00 | ||
ETP-46464 is a small molecule inhibitor of APLF, specifically targeting its DNA-binding domain. APLF is involved in DNA damage repair and chromatin remodeling. Inhibition of APLF disrupts its function in DNA repair processes, potentially leading to genomic instability. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is a selective inhibitor of ataxia-telangiectasia and Rad3-related (ATR) kinase. It prevents ATR-mediated signaling in response to DNA damage, leading to inhibition of cell cycle progression and impairment of DNA repair mechanisms. | ||||||
AZ20 | 1233339-22-4 | sc-503186 | 5 mg | $255.00 | 1 | |
AZ20 is a potent inhibitor of ataxia-telangiectasia mutated and Rad3-related (ATR) kinase. By targeting ATR, it disrupts the DNA damage response pathway, leading to impaired cell cycle checkpoints and DNA repair processes, which are critical for maintaining genome integrity. | ||||||
Ceralasertib | 1352226-88-0 | sc-507439 | 10 mg | $573.00 | ||
AZD6738 is an active ATR kinase inhibitor. It prevents ATR-mediated DNA damage checkpoint activation, leading to disruption of the G2/M checkpoint and sensitization of cancer cells to DNA-damaging agents, potentially enhancing the efficacy of chemotherapy. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
CGK733 is a selective inhibitor of ataxia-telangiectasia and Rad3-related (ATR) kinase. It disrupts ATR-mediated signaling and impairs the DNA damage response, ultimately leading to increased sensitivity of cancer cells to DNA-damaging agents and potential therapeutic benefits. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a selective inhibitor of checkpoint kinases 1 and 2 (Chk1 and Chk2). By blocking these kinases, it abrogates cell cycle checkpoints and enhances the cytotoxic effects of DNA-damaging agents. It has potential applications in cancer therapy, particularly in combination with chemotherapy. | ||||||
RAD51 Inhibitor B02 | 1290541-46-6 | sc-507533 | 10 mg | $95.00 | ||
B02 is a selective inhibitor of the E3 ubiquitin ligase RNF8, which is involved in the DNA damage response and repair pathways. Inhibition of RNF8 impairs the recruitment of repair factors to damaged sites, affecting DNA repair processes and potentially enhancing the effects of DNA-damaging agents. | ||||||