APC Inhibitors
APC inhibitors comprise a class of chemical compounds designed to modulate the activity of the adenomatous polyposis coli (APC) protein. APC plays a pivotal role in the regulation of the Wnt/β-catenin signaling pathway, influencing cellular processes such as proliferation, differentiation, and homeostasis. While direct inhibitors of APC are limited, several chemicals indirectly impact APC by modulating the Wnt pathway, revealing intricate regulatory mechanisms. One notable class of APC inhibitors includes tankyrase inhibitors like CCT251545, XAV939, NSC 668036, KYA1797K, and G007-LK. These compounds indirectly influence APC by stabilizing Axin, reinforcing the β-catenin destruction complex, and promoting the degradation of β-catenin. Consequently, these inhibitors suppress Wnt signaling, leading to a cascade of events that impact APC-regulated pathways.
Additionally, small molecules such as ICG-001, PKF118-310, PRI-724, FH535, and IWR-1-endo act as indirect APC inhibitors by specifically targeting components of the Wnt/β-catenin pathway. They disrupt the interaction between β-catenin and key coactivators, limiting β-catenin's transcriptional activity. This indirect modulation affects APC-regulated pathways, offering insights into the nuanced roles of APC in cellular processes. Furthermore, porcupine inhibitors like LGK-974 and Wnt-C59 impact APC indirectly by preventing the secretion and maturation of Wnt ligands, attenuating Wnt pathway activation. This intricate regulation alters APC-associated pathways, highlighting the interconnectedness of Wnt signaling and APC-mediated cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV939 is a tankyrase inhibitor that indirectly influences APC function. By inhibiting tankyrase, XAV939 stabilizes Axin, reinforcing the β-catenin destruction complex. This indirect modulation enhances APC's role in β-catenin degradation, resulting in suppressed Wnt signaling. XAV939 thus acts as an indirect inhibitor of APC by promoting the degradation of β-catenin and regulating APC-associated pathways involved in cellular homeostasis and proliferation. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC 668036 is an inhibitor of the Wnt/β-catenin pathway, impacting APC indirectly. This compound downregulates the expression of key Wnt pathway components, including β-catenin, and inhibits the nuclear translocation of β-catenin. By attenuating Wnt signaling, NSC 668036 affects APC-regulated pathways involved in cell differentiation and proliferation, showcasing its potential as an indirect inhibitor of APC-associated cellular processes. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $180.00 $651.00 | ||
PKF118-310 is a potent inhibitor of Wnt/β-catenin signaling, exerting indirect effects on APC. By preventing the interaction between β-catenin and Tcf4, PKF118-310 inhibits the transcriptional activity of β-catenin. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $260.00 | ||
PRI-724 is a selective inhibitor of the Wnt/β-catenin pathway, influencing APC indirectly. This compound specifically targets the interaction between β-catenin and CBP, inhibiting the transcriptional activity of β-catenin. By disrupting Wnt signaling, PRI-724 modulates APC-associated pathways involved in cellular proliferation and differentiation. Its selectivity and mechanism make PRI-724 a valuable tool for investigating the nuanced roles of APC in various physiological contexts. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 is a dual inhibitor of Wnt and peroxisome proliferator-activated receptor (PPAR), indirectly affecting APC. By inhibiting Wnt signaling, FH535 downregulates β-catenin expression and suppresses its nuclear translocation. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo is a small molecule inhibitor of Wnt/β-catenin signaling, exerting indirect effects on APC. By promoting β-catenin degradation, IWR-1-endo inhibits Wnt target gene expression. This indirect modulation influences APC-regulated pathways involved in cell fate determination and proliferation. IWR-1-endo's specificity for Wnt signaling makes it a valuable tool for investigating the complex interplay between APC and Wnt-associated cellular processes. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK-974 is a potent and specific porcupine inhibitor, impacting Wnt signaling and indirectly influencing APC. By inhibiting porcupine, LGK-974 prevents the acylation of Wnt ligands, suppressing Wnt pathway activation. This indirect modulation alters APC-associated pathways by attenuating Wnt signaling, impacting cellular processes governed by APC, such as cell proliferation and differentiation. | ||||||
G007-LK | 1380672-07-0 | sc-507467 | 1 mg | $48.00 | ||
G007-LK is a tankyrase inhibitor with potential indirect effects on APC. By inhibiting tankyrase, G007-LK stabilizes Axin, reinforcing the β-catenin destruction complex. This indirect modulation enhances APC's role in β-catenin degradation, impacting Wnt signaling. | ||||||