Items 141 to 141 of 141 total
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Irinotecan hydrochloride trihydrate | 136572-09-3 | sc-202186 sc-202186A | 5 mg 25 mg | $102.00 $354.00 | 6 | |
Irinotecan hydrochloride trihydrate is a camptothecin derivative that exerts its antitumor effects through the inhibition of topoisomerase I, an enzyme crucial for DNA replication and transcription. By stabilizing the enzyme-DNA complex, it induces DNA damage and triggers cellular stress responses. This compound's unique mechanism leads to the accumulation of single-strand breaks, ultimately resulting in apoptosis. Its pharmacokinetics involve active metabolites that further enhance its therapeutic profile. |