Irinotecan hydrochloride trihydrate: sc-202186. Western blot analysis of cleaved PARP-1 expression in untreated (A) and Irinotecan hydrochloride trihydrate treated (B) HL-60 whole cell lysates. Note cleaved PARP-1 expression in lane B. Antibody tested: PARP-1 (H-300): sc-25780.
Irinotecan hydrochloride trihydrate (CAS 136572-09-3)
See product citations (6)
Alternate Names:
Camptosar; Campto; CPT-11
Application:
Irinotecan hydrochloride trihydrate is an inhibitor of Topo I
CAS Number:
136572-09-3
Purity:
≥99%
Molecular Weight:
677.1
Molecular Formula:
C33H38N4O6•HCl•3H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Irinotecan hydrochloride trihydrate is a potent inhibitor of topoisomerase I, an enzyme involved in DNA replication and transcription. Irinotecan hydrochloride trihydrate exerts its cytotoxic effects by stabilizing the cleavable complex formed by topoisomerase I and DNA, leading to DNA damage and ultimately cell death. Irinotecan hydrochloride trihydrate is a derivative of camptothecin, a product isolated from the Chinese tree Camptotheca acuminata.
Irinotecan hydrochloride trihydrate (CAS 136572-09-3) References
- Therapeutic advances in small cell lung cancer. | Worden, FP. and Kalemkerian, GP. 2000. Expert Opin Investig Drugs. 9: 565-79. PMID: 11060696
- Human DNA-Topoisomerases - Diagnostic and Therapeutic Implications for Cancer. | Kellner, U., et al. 2000. Onkologie. 23: 424-430. PMID: 11441236
- Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis. | Takeba, Y., et al. 2007. J Pharmacol Sci. 104: 232-42. PMID: 17609585
- Synthesis and antitumor activity of 20(S)-camptothecin derivatives: carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin. | Sawada, S., et al. 1991. Chem Pharm Bull (Tokyo). 39: 1446-50. PMID: 1934165
- Irinotecan hydrochloride trihydrate loaded folic acid-tailored solid lipid nanoparticles for targeting colorectal cancer: development, characterization, and in vitro cytotoxicity study using HT-29 cells. | Rajpoot, K. and Jain, SK. 2019. J Microencapsul. 36: 659-676. PMID: 31495238
- Enhanced proliferation inhibition and apoptosis in glioma cells elicited by combination of irinotecan and imatinib. | Lu, J., et al. 2020. Eur J Pharmacol. 874: 173022. PMID: 32084420
- Development and Optimization of Irinotecan-Loaded PCL Nanoparticles and Their Cytotoxicity against Primary High-Grade Glioma Cells. | Mahmoud, BS. and McConville, C. 2021. Pharmaceutics. 13: PMID: 33924355
- A High Throughput Approach Based on Dynamic High Pressure for the Encapsulation of Active Compounds in Exosomes for Precision Medicine. | Romano, E., et al. 2021. Int J Mol Sci. 22: PMID: 34576059
- PLGA nanoparticles delivering CPT-11 combined with focused ultrasound inhibit platinum resistant ovarian cancer. | Zhu, X., et al. 2021. Transl Cancer Res. 10: 1732-1743. PMID: 35116498
- Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. | Takasuna, K., et al. 1996. Cancer Res. 56: 3752-7. PMID: 8706020
- Induction of tumor necrosis factor by a camptothecin derivative, irinotecan, in mice and human mononuclear cells. | Goto, S., et al. 1996. Anticancer Res. 16: 2507-11. PMID: 8917343
- Synthesis of CPT-11 (irinotecan hydrochloride trihydrate). | Sawada, S., et al. 1996. Ann N Y Acad Sci. 803: 13-28. PMID: 8993496
- Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats. | Takasuna, K., et al. 1998. Cancer Chemother Pharmacol. 42: 280-6. PMID: 9744772
Inhibitor of:
Topo I.Activator of:
p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Irinotecan hydrochloride trihydrate, 5 mg | sc-202186 | 5 mg | $102.00 | |||
Irinotecan hydrochloride trihydrate, 25 mg | sc-202186A | 25 mg | $354.00 |