ANT2 Activators
The class of ANT2 activators presents a diverse repertoire of chemicals that intricately modulate cellular energy status and mitochondrial function, focusing on the activation of AMP-activated protein kinase (AMPK), a central regulator of energy homeostasis. The activation of AMPK, in turn, enhances mitochondrial biogenesis and function, indirectly supporting the activation of the adenine nucleotide translocator 2 (ANT2). Dichloroacetate (DCA) serves as a pyruvate dehydrogenase kinase (PDK) inhibitor, promoting pyruvate dehydrogenase (PDH) activity and enhancing mitochondrial respiration. This action contributes to improved cellular energy status and supports the indirect activation of ANT2. Resveratrol activates AMPK, positively influencing mitochondrial health and indirectly supporting ANT2 by enhancing cellular energy homeostasis. AICAR, mimicking AMP, activates AMPK, influencing mitochondrial processes, and supporting ANT2. Oligomycin A, an inhibitor of mitochondrial ATP synthase, activates AMPK, positively impacting ANT2 by enhancing mitochondrial function.
Metformin disrupts mitochondrial complex I, leading to AMPK activation and indirect modulation of ANT2. DNP (2,4-Dinitrophenol) induces mitochondrial uncoupling, activating AMPK and influencing ANT2. FCCP (Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone), a mitochondrial uncoupler, activates AMPK and indirectly supports ANT2 by enhancing cellular energy status. Berberine activates AMPK, improving mitochondrial health, and indirectly influencing ANT2. IACS-010759 (Oltipraz) inhibits thioredoxin reductase, leading to ROS production and AMPK activation, supporting ANT2. A769662, an allosteric AMPK activator, enhances cellular energy status, positively impacting mitochondrial health and ANT2. Salicylate inhibits mitochondrial complex I, activates AMPK, and indirectly influences ANT2. Nitric oxide donors, such as sodium nitroprusside (SNP), increase intracellular NO levels, activating AMPK and supporting ANT2. The collective action of these chemicals forms a comprehensive toolkit for researchers exploring the modulation of ANT2. By targeting AMPK and mitochondrial function through diverse pathways, these activators provide valuable insights into the complex regulatory networks governing cellular energy homeostasis and the integral role of ANT2 in this intricate interplay.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $61.00 $128.00 | 5 | |
Dichloroacetate (DCA) acts as a pyruvate dehydrogenase kinase (PDK) inhibitor, promoting the activity of pyruvate dehydrogenase (PDH). This leads to increased mitochondrial respiration, influencing cellular metabolism. ANT2 activation is indirectly supported as enhanced PDH activity can augment the production of respiratory substrates that impact the electron transport chain, contributing to ANT2 activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, activates AMP-activated protein kinase (AMPK), a key energy sensor. This activation enhances mitochondrial biogenesis and function. AMPK-mediated improvement in mitochondrial health indirectly supports ANT2 activation, as increased mitochondrial function positively impacts adenine nucleotide transport. AMPK, by influencing cellular energy status, can modulate mitochondrial processes that favor ANT2 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMP analog, activates AMP-activated protein kinase (AMPK). AMPK activation enhances mitochondrial function and biogenesis. The resultant improvement in cellular energy status indirectly supports ANT2 activation by promoting mitochondrial processes, influencing adenine nucleotide transport. AICAR's impact on AMPK provides a regulatory link that can modulate mitochondrial health, influencing ANT2 activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin, an anti-diabetic drug, indirectly activates AMP-activated protein kinase (AMPK) by disrupting mitochondrial complex I. This activation enhances mitochondrial function and biogenesis. The improved mitochondrial health, influenced by AMPK, indirectly supports ANT2 activation by positively impacting adenine nucleotide transport. Metformin's role in AMPK activation provides a link between its anti-diabetic effects and modulation of ANT2 activity. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $59.00 | 2 | |
DNP disrupts oxidative phosphorylation, causing mitochondrial uncoupling. The resultant increase in cellular energy demand activates AMP-activated protein kinase (AMPK). AMPK activation enhances mitochondrial biogenesis and function, indirectly supporting ANT2 activation. DNP's impact on AMPK provides a link between mitochondrial uncoupling and the modulation of ANT2 activity, reflecting the interconnectedness of cellular energy regulation. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP, a mitochondrial uncoupler, disrupts oxidative phosphorylation, activating AMP-activated protein kinase (AMPK). This activation enhances mitochondrial function and biogenesis. Improved mitochondrial health, influenced by AMPK, indirectly supports ANT2 activation by positively impacting adenine nucleotide transport. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy status. This activation enhances mitochondrial biogenesis and function. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
IACS-010759 inhibits thioredoxin reductase, leading to increased reactive oxygen species (ROS) production. ROS activates AMP-activated protein kinase (AMPK), enhancing mitochondrial biogenesis and function. Improved mitochondrial health, influenced by AMPK, indirectly supports ANT2 activation by positively impacting adenine nucleotide transport. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an allosteric activator of AMP-activated protein kinase (AMPK), enhances cellular energy status by promoting AMPK activation. This activation improves mitochondrial function and biogenesis, indirectly supporting ANT2 activation. A769662's impact on AMPK provides a regulatory link that can modulate mitochondrial health, influencing adenine nucleotide transport and contributing to ANT2 activation. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate activates AMP-activated protein kinase (AMPK) through inhibition of mitochondrial complex I. This activation enhances mitochondrial function and biogenesis. The improved mitochondrial health, influenced by AMPK, indirectly supports ANT2 activation by positively impacting adenine nucleotide transport. Salicylate's action on AMPK provides a link between its anti-inflammatory effects and modulation of ANT2 activity, revealing interconnected cellular responses. | ||||||