AMPKγ2 Inhibitors
AMPKγ2 inhibitors belong to a class of small-molecule compounds designed to selectively target the gamma-2 subunit of AMP-activated protein kinase (AMPK). AMPK is a critical enzyme involved in cellular energy regulation and metabolic homeostasis. The gamma-2 subunit functions as one of the regulatory components of the AMPK complex. Inhibitors of this subunit are developed to interfere with its binding sites and disrupt its association with other subunits, modulating the overall activity of AMPK. By inhibiting AMPKγ2, these compounds aim to influence various downstream signaling pathways involved in energy metabolism, glucose uptake, and lipid synthesis, among other cellular processes.
The mechanism of action of AMPKγ2 inhibitors may involve competitive binding with the gamma-2 subunit or causing structural changes that prevent its functional interaction within the AMPK complex. These inhibitors serve as valuable tools for researchers to investigate the role of AMPKγ2 in cellular signaling and metabolic regulation, providing insights into the molecular mechanisms governing AMPK activity and its impact on cellular physiology. Continued research in this area may further elucidate the significance of AMPKγ2 and its potential as a target for various scientific inquiries.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
This is one of the most widely used AMPK inhibitors, which targets both AMPKα and AMPKγ subunits. It effectively inhibits AMPK activity by competing with ATP for binding to the kinase domain. | ||||||
Vidarabine | 5536-17-4 | sc-205881 sc-205881A | 100 mg 500 mg | $52.00 $137.00 | 1 | |
Also known as vidarabine, Ara-A is an antiviral drug that can inhibit AMPKγ2 activity, although its use as an AMPK inhibitor is not its primary function. | ||||||