Amphiphysin II Activators
Amphiphysin II activators belong to a class of chemical compounds that play a pivotal role in regulating cellular processes, particularly those involved in intracellular trafficking and membrane dynamics. These activators are characterized by their ability to modulate the function of amphiphysin II, a protein predominantly found in nerve terminals and synaptic vesicles. Amphiphysin II is renowned for its role in clathrin-mediated endocytosis, a fundamental cellular process responsible for the internalization of molecules at the plasma membrane. It is composed of multiple domains, including an N-terminal BAR (Bin-Amphiphysin-Rvs) domain, a central coiled-coil domain, and a C-terminal SH3 (Src homology 3) domain. The BAR domain allows amphiphysin II to sense and shape membranes, while the SH3 domain mediates protein-protein interactions.
Amphiphysin II activators specifically target this multifaceted protein and can enhance its functions, particularly in membrane curvature generation and vesicle scission during endocytosis. By binding to amphiphysin II, these activators can influence the structural conformation of the protein, promoting its association with membranes and facilitating membrane bending. This phenomenon is vital in the formation of clathrin-coated pits, where cellular cargo is internalized via vesicles. The modulation of amphiphysin II activity by these compounds underscores their importance in deciphering the intricate mechanisms of cellular trafficking and membrane dynamics, shedding light on fundamental cellular processes beyond their potential applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol found in grapes, has been shown to activate sirtuin proteins, which can influence the expression of various genes, potentially including Amphiphysin II. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Present in cruciferous vegetables, sulforaphane activates the Nrf2 pathway, potentially enhancing the expression of proteins involved in cellular defense, possibly including Amphiphysin II. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, has anti-inflammatory properties and has been shown to modulate gene expression, which could include upregulation of Amphiphysin II. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 modulates gene expression through its receptor, VDR. This modulation could extend to genes related to endocytosis and membrane dynamics, including Amphiphysin II. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, EGCG has been shown to modulate gene expression and protein activity, potentially influencing the expression of Amphiphysin II. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, regulates gene expression through its receptors, which could lead to changes in the expression levels of proteins like Amphiphysin II. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a crucial trace element that plays a role in regulating gene expression. Its presence can influence the expression of various proteins, possibly including Amphiphysin II. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium is vital for the proper function of selenoproteins, which are involved in antioxidative processes, and its availability can influence the expression of other proteins. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine has been shown to influence cellular processes and gene expression, which could potentially extend to the regulation of Amphiphysin II levels. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK, leading to various cellular effects, including potential changes in protein expression patterns. | ||||||