Alphavirus Activators
The chemical class termed Alphavirus Activators encompasses a diverse group of compounds that can potentially influence cellular environments or pathways utilized by Alphaviruses during their replication cycle. These compounds do not activate the virus in a direct manner; rather, they may create conditions that are favorable for viral replication or alter cellular mechanisms that the virus exploits. Compounds like Chloroquine, Ammonium Chloride, and Bafilomycin A1 affect endosomal acidification, a key step in the entry process of many viruses, including some Alphaviruses. By modulating the pH of endosomes, these chemicals could potentially influence the efficiency of viral entry and uncoating. Azithromycin and Dexamethasone, through their immunomodulatory effects, might alter the host's immune response in a manner that inadvertently favors viral replication.
Cyclosporine A and Rapamycin, known for their immunosuppressive and autophagy-modulating effects respectively, could impact cellular pathways or environmental conditions leveraged by Alphaviruses. Sodium Butyrate and Niclosamide, by altering gene expression and endocytic pathways, may influence the cellular environment in a way that affects Alphavirus replication. Deferoxamine, Prochlorperazine, and U18666A, through their effects on cellular oxidative states, endosomal pathways, and cholesterol metabolism, represent additional mechanisms by which the replication of Alphaviruses might be indirectly influenced.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
A lysosomotropic agent that raises endosomal pH, potentially affecting the entry and uncoating of Alphaviruses. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $51.00 $101.00 $255.00 $357.00 $714.00 | 17 | |
An antibiotic that may affect viral replication through its immunomodulatory effects or influence on cellular pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A corticosteroid that can suppress the immune response, potentially impacting the replication of Alphaviruses by reducing host defenses. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that may impact cellular pathways exploited by Alphaviruses, potentially enhancing viral replication. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, known to affect autophagy, which could influence Alphavirus replication indirectly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor, potentially impacting cellular gene expression in a way that could influence Alphavirus replication. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
An inhibitor of vacuolar-type H+-ATPase, affecting endosomal acidification and potentially the entry mechanism of Alphaviruses. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
An anthelmintic drug that may disrupt endocytic pathways, potentially influencing Alphavirus entry and replication. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
An iron chelator that can affect cellular oxidative states and potentially influence pathways utilized by Alphaviruses. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
Influences cholesterol transport and storage, potentially affecting membrane compositions and the replication cycle of Alphaviruses. | ||||||